Molecular structure of Trelagliptin, CAS Number: 865759-25-7
Trelagliptin (CAS 865759-25-7)
Alternate Names:
2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluoro-benzonitrile
CAS Number:
865759-25-7
Molecular Weight:
357.4
Molecular Formula:
C18H20FN5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Trelagliptin (CAS 865759-25-7) References
- First novel once-weekly DPP-4 inhibitor, trelagliptin, for the treatment of type 2 diabetes mellitus. | Kaku, K. 2015. Expert Opin Pharmacother. 16: 2539-47. PMID: 26523434
- Trelagliptin succinate: DPP-4 inhibitor to improve insulin resistance in adipocytes. | Liu, Z., et al. 2020. Biomed Pharmacother. 125: 109952. PMID: 32036216
- The protective effects of trelagliptin on high-fat diet-induced nonalcoholic fatty liver disease in mice. | Wang, G., et al. 2021. J Biochem Mol Toxicol. 35: e22696. PMID: 33421258
- Trelagliptin Mitigates Macrophage Infiltration by Preventing the Breakdown of the Blood-Brain Barrier in the Brain of Middle Cerebral Artery Occlusion Mice. | Zang, L., et al. 2021. Chem Res Toxicol. 34: 1016-1023. PMID: 33728903
- Trelagliptin stimulates osteoblastic differentiation by increasing runt-related transcription factor 2 (RUNX2): a therapeutic implication in osteoporosis. | Shao, H., et al. 2021. Bioengineered. 12: 960-968. PMID: 33734011
- Trelagliptin Alleviates Lipopolysaccharide (LPS)-Induced Inflammation and Oxidative Stress in Acute Lung Injury Mice. | Zhou, J., et al. 2021. Inflammation. 44: 1507-1517. PMID: 33751359
- The anti-diabetic drug trelagliptin induces vasodilation via activation of Kv channels and SERCA pumps. | Heo, R., et al. 2021. Life Sci. 283: 119868. PMID: 34358551
- Trelagliptin ameliorates oxygen-glucose deprivation/reperfusion (OGD/R)-induced mitochondrial dysfunction and metabolic disturbance of endothelial cells. | Zhang, Y., et al. 2021. Hum Cell. 34: 1717-1726. PMID: 34435315
- Trelagliptin ameliorates IL-1β-impaired chondrocyte function via the AMPK/SOX-9 pathway. | Liu, J., et al. 2021. Mol Immunol. 140: 70-76. PMID: 34666245
- Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway. | Lei, M., et al. 2023. Exp Gerontol. 182: 112307. PMID: 37804920
Inhibitor of:
CD26, DPP10, and DPPA4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trelagliptin, 5 mg | sc-507285 | 5 mg | $405.00 |