TMPH hydrochloride CAS: 849461-91-2
MF: C16H31NO2•HCl
MW: 305.88
A potent inhibitor of neuronal AChRs.

TMPH hydrochloride (CAS 849461-91-2)

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Application: TMPH hydrochloride is a potent inhibitor of neuronal AChRs
CAS Number: 849461-91-2
Molecular Weight: 305.88
Molecular Formula: C16H31NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

TMPH hydrochloride is a potent inhibitor of neuronal AChRs. Evaluation of AChR subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal AChR formed by the pairwise combination of the most abundant neuronal α (i.e., α3 and α4) and β subunits (β2 and β4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (α1β1γδ) or α7 receptors. However, the inhibition of neuronal β subunit-containing receptors was also decreased if any of the nonessential subunits α5, α6, or β3 were coexpressed. This decrease in inhibition is shown to be associated with a single amino acid present in the second transmembrane domain of these subunits. TMPH ability to relate the diverse central nervous system effects to specific AChR subtypes makes it a helpful tool for studying the functional roles of AChR.


References

Papke, R.L. et al., The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Mol. Pharmacol. 67, 1977-1990, (2005)

Physical State :
Solid
Solubility :
Soluble in water
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16079014
SMILES :
CCCCCCC(=O)OC1CC(NC(C1)(C)C)(C)C.Cl

Download SDS (MSDS)

Certificate of Analysis

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