TMPH hydrochloride (CAS 849461-91-2)
QUICK LINKS
TMPH hydrochloride is a potent inhibitor of neuronal AChRs. Evaluation of AChR subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal AChR formed by the pairwise combination of the most abundant neuronal alpha (i.e., alpha3 and alpha4) and beta subunits (beta2 and beta4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (alpha1beta1gammadelta) or alpha7 receptors. However, the inhibition of neuronal beta subunit-containing receptors was also decreased if any of the nonessential subunits alpha5, alpha6, or beta3 were coexpressed. This decrease in inhibition is shown to be associated with a single amino acid present in the second transmembrane domain of these subunits. TMPH ability to relate the diverse central nervous system effects to specific AChR subtypes makes it a helpful tool for studying the functional roles of AChR.
TMPH hydrochloride (CAS 849461-91-2) References
- Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. | Pinnock, F., et al. 2015. Front Behav Neurosci. 9: 30. PMID: 25717295
- Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models. | Tanimura, A., et al. 2019. Neuron. 101: 444-458.e6. PMID: 30658860
- High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells. | Li, W., et al. 2023. iScience. 26: 106156. PMID: 36852281
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMPH hydrochloride, 5 mg | sc-253705 | 5 mg | $219.00 |