Thyroxine Antibody (1H1): sc-52247

Thyroxine Antibody (1H1) is a mouse monoclonal IgG1 antibody that detects the Thyroxine protein of mouse, rat, and human origin by enzyme-linked immunosorbent assay (ELISA). Anti-Thyroxine antibody (1H1) is available as the non-conjugated monoclonal isotype antibody. Thyroxine, also known as T4, is a crucial tyrosine-based hormone synthesized by the thyroid glands, playing a vital role in regulating metabolism and energy levels in the body. T4 circulates primarily bound to carrier proteins, with only a small fraction existing in its free form. Thyroxine increases the basal metabolic rate, enhances protein synthesis, and heightens the body′s sensitivity to catecholamines, such as adrenaline. T4 is essential for proper fetal development; insufficient levels during pregnancy can lead to severe consequences, including irreversible brain damage in the fetus. The conversion of free T4 to Triiodothyronine (T3) in peripheral tissues further underscores Thyroxine′s significance in maintaining metabolic homeostasis. In cases of hypothyroidism, where the thyroid gland is underactive, T4 supplementation is a common therapeutic approach, often combined with T3 to restore normal physiological function.

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Thyroxine Antibody (1H1) References:

1. [Triiodothyronine and thyroxin binding to red blood cells in children and adolescents with thyroid cancer].  |  Fedorovich, EI. and Demidchik, IuE. 2002. Vopr Onkol. 48: 661-3. PMID: 12530259
2. Thyroid hormones as molecular determinants of thermogenesis.  |  Silvestri, E., et al. 2005. Acta Physiol Scand. 184: 265-83. PMID: 16026419
3. Naturally occurring mutations in the thyroglobulin gene.  |  Vono-Toniolo, J., et al. 2005. Thyroid. 15: 1021-33. PMID: 16187910
4. Neonatal screening for congenital hypothyroidism based on thyroxine, thyrotropin, and thyroxine-binding globulin measurement: potentials and pitfalls.  |  Kempers, MJ., et al. 2006. J Clin Endocrinol Metab. 91: 3370-6. PMID: 16787990
5. Thyroxine: cause and cure for headache.  |  Shaikh, MG., et al. 2006. Acta Paediatr. 95: 632-3. PMID: 16825155
6. The effect of L-thyroxine supplementation in a neonatal rat model of ROP.  |  Wren, SM., et al. 2006. Curr Eye Res. 31: 669-74. PMID: 16877275
7. Structural mechanism for the carriage and release of thyroxine in the blood.  |  Zhou, A., et al. 2006. Proc Natl Acad Sci U S A. 103: 13321-6. PMID: 16938877
8. [Hyperthyroidism].  |  Mezosi, E. 2006. Orv Hetil. 147: 1309-14. PMID: 16999016
9. Iodine supplementation for pregnancy and lactation-United States and Canada: recommendations of the American Thyroid Association.  |  , ., et al. 2006. Thyroid. 16: 949-51. PMID: 17042677

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Thyroxine Antibody (1H1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Thyroxine Antibody (1H1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Thyroxine Antibody (1H1) Specifications

Alternate Product Name: Thyroxine

Product Clone Name: 1H1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Thyroxine

Epitope Species: human

Product Reactivity/Detection: Thyroxine

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Thyroxine Antibody (1H1): N/A