Molecular structure of tert-butyl N-methylcarbamate, CAS Number: 16066-84-5
tert-butyl N-methylcarbamate (CAS 16066-84-5)
Alternate Names:
Methyl-carbamic acid tert-butyl ester
CAS Number:
16066-84-5
Molecular Weight:
131.17
Molecular Formula:
C6H13NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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tert-Butyl-N-methylcarbamate is an amine compound used in the synthesis of styrene. It is also a ligand and serves as a sodium hydrogen amide in amination reactions. The tert-butyl group can be replaced with various substituents like carboxylic acid, ester, or nitrile, leading to diverse chemical products. Tert-Butyl-N-methylcarbamate plays a role in the production of nicotine from hydrogen sulfate. It also acts as a substituent in the synthetic pathway of PF-06463922—a macrocyclic inhibitor targeting Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1).
tert-butyl N-methylcarbamate (CAS 16066-84-5) References
- Highly predictive hologram QSAR models of nitrile-containing cruzain inhibitors. | Silva, DG., et al. 2017. J Biomol Struct Dyn. 35: 3232-3249. PMID: 27809673
- Direct catalytic enantioselective amination of ketones for the formation of tri- and tetrasubstituted stereocenters. | Trost, BM., et al. 2018. Chem Sci. 9: 2975-2980. PMID: 29719678
- Efficient and selective hydrogenation of amides to alcohols and amines using a well-defined manganese-PNN pincer complex. | Papa, V., et al. 2017. Chem Sci. 8: 3576-3585. PMID: 30155202
- Synthesis and Evaluation of PPARδ Agonists That Promote Osteogenesis in a Human Mesenchymal Stem Cell Culture and in a Mouse Model of Human Osteoporosis. | Kress, BJ., et al. 2021. J Med Chem. 64: 6996-7032. PMID: 33988379
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
tert-butyl N-methylcarbamate, 1 g | sc-356116 | 1 g | $69.00 | |||
tert-butyl N-methylcarbamate, 5 g | sc-356116A | 5 g | $301.00 |