Terameprocol (CAS 24150-24-1)
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Tetramethyl Nordihydroguaiaretic Acid is a compound that functions as a potent antioxidant and free radical scavenger. It acts by inhibiting the activity of lipoxygenase enzymes, which are involved in the metabolism of arachidonic acid and the production of leukotrienes. By doing so, it helps to prevent lipid peroxidation and oxidative damage to cells and tissues. It may act to inhibit the activation of transcription factors such as NF-κB, which play a role in the regulation of genes involved in inflammation and immune responses. Tetramethyl Nordihydroguaiaretic Acid also exhibits anti-inflammatory properties by reducing the production of pro-inflammatory cytokines and chemokines. To modulate the expression of genes involved in cell cycle regulation and apoptosis, suggesting a potential role in controlling cell proliferation and survival. Tetramethyl Nordihydroguaiaretic Acid functions as a multifaceted molecule with antioxidant, anti-inflammatory, and gene regulatory activities, making it useful for investigating cellular processes and molecular pathways.
Terameprocol (CAS 24150-24-1) References
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- Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines. | Eads, D., et al. 2009. J Inflamm (Lond). 6: 2. PMID: 19133137
- Inhibition of poxvirus growth by Terameprocol, a methylated derivative of nordihydroguaiaretic acid. | Pollara, JJ., et al. 2010. Antiviral Res. 88: 287-95. PMID: 20888364
- Terameprocol (tetra-O-methyl nordihydroguaiaretic acid), an inhibitor of Sp1-mediated survivin transcription, induces radiosensitization in non-small cell lung carcinoma. | Sun, Y., et al. 2011. J Thorac Oncol. 6: 8-14. PMID: 21107289
- Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-κB-dependent transcription of TNF-α and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA. | Oyegunwa, AO., et al. 2010. J Inflamm (Lond). 7: 59. PMID: 21138578
- Activated oncogenic pathways and therapeutic targets in extranodal nasal-type NK/T cell lymphoma revealed by gene expression profiling. | Ng, SB., et al. 2011. J Pathol. 223: 496-510. PMID: 21294123
- Restraining the flexibility of the central linker in terameprocol results in constrained analogs with improved growth inhibitory activity. | Ho, SS. and Go, ML. 2013. Bioorg Med Chem Lett. 23: 6127-33. PMID: 24080463
- MYD88-independent growth and survival effects of Sp1 transactivation in Waldenstrom macroglobulinemia. | Fulciniti, M., et al. 2014. Blood. 123: 2673-81. PMID: 24622324
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- Synergistic targeting of Sp1, a critical transcription factor for myeloma cell growth and survival, by panobinostat and proteasome inhibitors. | Bat-Erdene, A., et al. 2016. Oncotarget. 7: 79064-79075. PMID: 27738323
- The combination of everolimus and terameprocol exerts synergistic antiproliferative effects in endometrial cancer: molecular role of insulin-like growth factor binding protein 2. | Chao, A., et al. 2018. J Mol Med (Berl). 96: 1251-1266. PMID: 30298385
- Quantitation of terameprocol in human plasma by liquid chromatography-tandem mass spectrometry. | Anders, NM., et al. 2022. J Pharm Biomed Anal. 209: 114525. PMID: 34906921
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Terameprocol, 50 mg | sc-224304 | 50 mg | $28.00 | |||
Terameprocol, 100 mg | sc-224304A | 100 mg | $44.00 | |||
Terameprocol, 500 mg | sc-224304B | 500 mg | $184.00 | |||
Terameprocol, 1 g | sc-224304C | 1 g | $321.00 |