Molecular structure of TER14687, CAS Number: 16931-84-3
TER14687 (CAS 16931-84-3)
Application:
TER14687 is a compound preventing normal translocation of PKCq in T cells
CAS Number:
16931-84-3
Purity:
>95%
Molecular Weight:
225.71
Molecular Formula:
C12H16ClNO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TER14687 blocks the association between protein kinase Cq-V1 and p59fyn in a yeast reporter assay. TER14687 also prevents normal translocation of PKCq in T cells. The compound has no effect on other PKC isozymes in Jurkat or normal T cells.
TER14687 (CAS 16931-84-3) References
- Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn. | Ron, D., et al. 1999. J Biol Chem. 274: 19003-10. PMID: 10383400
- Pharmacological regulation of network kinetics by protein kinase C localization. | Mochly-Rosen, D. and Kauvar, LM. 2000. Semin Immunol. 12: 55-61. PMID: 10723798
- Prostratin antagonizes HIV latency by activating NF-kappaB. | Williams, SA., et al. 2004. J Biol Chem. 279: 42008-17. PMID: 15284245
- Superantigen-induced corticosteroid resistance of human T cells occurs through activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK-ERK) pathway. | Li, LB., et al. 2004. J Allergy Clin Immunol. 114: 1059-69. PMID: 15536411
- Human immunodeficiency virus reactivation by phorbol esters or T-cell receptor ligation requires both PKCalpha and PKCtheta. | Trushin, SA., et al. 2005. J Virol. 79: 9821-30. PMID: 16014943
- Shared peripheral blood biomarkers for Alzheimer's disease, major depressive disorder, and type 2 diabetes and cognitive risk factor analysis. | Zhang, Y., et al. 2023. Heliyon. 9: e14653. PMID: 36994393
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TER14687, 10 mg | sc-204336 | 10 mg | $180.00 | |||
TER14687, 50 mg | sc-204336A | 50 mg | $750.00 |