TCR V α 24 J α 18 Antibody (6B11): sc-81719

TCR V α 24 J α 18 Antibody (6B11) is a mouse monoclonal IgG1 antibody that detects the TCR V alpha 24 J alpha 18 protein of human origin by flow cytometry (FCM). TCR V α 24 J α 18 (6B11) antibody is available as the non-conjugated format. The T cell antigen receptor (TCR) plays a crucial role in the immune response by recognizing diverse foreign antigens, which is essential for T cell activation and immune response. The TCR is a heterodimer composed of either alpha and beta chains or gamma and delta chains, with most T cells (about 95%) expressing the alpha/beta heterodimer. TCR specificity diversity occurs through somatic recombination, involving variable (V), diversity (D), and joining (J) gene segments rearrangement during T cell development. TCR beta and gamma chain genes exist in separate loci, while TCR alpha and delta chain genes share a single locus. TCR V α 24 J α 18 (6B11) monoclonal antibody recognizes a specific alpha chain important for detecting antigens presented by non-classical MHC class I molecule, CD1d, which activates invariant natural killer T (iNKT) cells. These iNKT cells bridge innate and adaptive immunity, making TCR V α 24 J α 18 crucial for understanding immune responses and therapeutic applications.

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TCR V α 24 J α 18 Antibody (6B11) References:

1. The role of recombination activating gene (RAG) reinduction in thymocyte development in vivo.  |  Yannoutsos, N., et al. 2001. J Exp Med. 194: 471-80. PMID: 11514603
2. T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.  |  Bassing, CH., et al. 2003. Proc Natl Acad Sci U S A. 100: 2598-603. PMID: 12604775
3. Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure.  |  Hawwari, A. and Krangel, MS. 2005. J Exp Med. 202: 467-72. PMID: 16087716
4. MR1-restricted V alpha 19i mucosal-associated invariant T cells are innate T cells in the gut lamina propria that provide a rapid and diverse cytokine response.  |  Kawachi, I., et al. 2006. J Immunol. 176: 1618-27. PMID: 16424191
5. A model for TCR gene segment use.  |  Warmflash, A. and Dinner, AR. 2006. J Immunol. 177: 3857-64. PMID: 16951348
6. A unique T cell receptor discovered in marsupials.  |  Parra, ZE., et al. 2007. Proc Natl Acad Sci U S A. 104: 9776-81. PMID: 17535902
7. Developmental stage-specific regulation of TCR-alpha-chain gene assembly by intrinsic features of the TEA promoter.  |  Huang, CY. and Sleckman, BP. 2007. J Immunol. 179: 449-54. PMID: 17579065
8. Germline-encoded recognition of diverse glycolipids by natural killer T cells.  |  Scott-Browne, JP., et al. 2007. Nat Immunol. 8: 1105-13. PMID: 17828267
9. Accessibility control of variable region gene assembly during T-cell development.  |  Sleckman, BP., et al. 1998. Immunol Rev. 165: 121-30. PMID: 9850857

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TCR V α 24 J α 18 Antibody (6B11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TCR V α 24 J α 18 Antibody (6B11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TCR V α 24 J α 18 Antibody (6B11) Specifications

Alternate Product Name: TCR V α 24 J α 18

Product Clone Name: 6B11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: TCR V α 24 J α 18

Epitope Species: human

Product Reactivity/Detection: a unique determinant in the CDR3 region of the invariant TCR V α 24 J α 18

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: FCM

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TCR V α 24 J α 18 Antibody (6B11): N/A