TCIRG1 Antibody (6H3): sc-293491

TCIRG1 Antibody (6H3) is a mouse monoclonal IgG2a kappa light chain antibody that detects the TCIRG1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-TCIRG1 antibody (6H3) is available as a non-conjugated format. TCIRG1 protein, also known as T-cell immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3, plays a crucial role in the V-ATPase complex, which is essential for acidifying intracellular compartments and facilitating various cellular processes, including protein degradation and nutrient sensing. TCIRG1 protein is primarily located in the lysosomal membrane, where TCIRG1 contributes to the proton transport necessary for maintaining the acidic environment required for optimal lysosomal function. Proper functioning of TCIRG1 is vital for T-cell activation and osteoclast differentiation, and mutations in the TCIRG1 gene can lead to osteopetrosis autosomal recessive type 1, a condition characterized by excessive bone density due to impaired bone resorption. Understanding TCIRG1′s role in these processes highlights TCIRG1′s importance in both immune response and bone metabolism, making TCIRG1 (6H3) monoclonal antibody a valuable tool for research in these areas.

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TCIRG1 Antibody (6H3) References:

1. Genomic organization of the gene coding for TIRC7, a novel membrane protein essential for T cell activation.  |  Heinemann, T., et al. 1999. Genomics. 57: 398-406. PMID: 10329006
2. Localization of the gene causing autosomal dominant osteopetrosis type I to chromosome 11q12-13.  |  Van Hul, E., et al. 2002. J Bone Miner Res. 17: 1111-7. PMID: 12054167
3. Sibling pair linkage and association studies between peak bone mineral density and the gene locus for the osteoclast-specific subunit (OC116) of the vacuolar proton pump on chromosome 11p12-13.  |  Carn, G., et al. 2002. J Clin Endocrinol Metab. 87: 3819-24. PMID: 12161516
4. Association between a polymorphism affecting an AP1 binding site in the promoter of the TCIRG1 gene and bone mass in women.  |  Sobacchi, C., et al. 2004. Calcif Tissue Int. 74: 35-41. PMID: 14523594
5. Identification of new alternative splice events in the TCIRG1 gene in different human tissues.  |  Smirnova, AS., et al. 2005. Biochem Biophys Res Commun. 330: 943-9. PMID: 15809087
6. TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression.  |  Bulwin, GC., et al. 2006. J Immunol. 177: 6833-41. PMID: 17082597
7. Characterization of a novel Alu-Alu recombination-mediated genomic deletion in the TCIRG1 gene in five osteopetrotic patients.  |  Pangrazio, A., et al. 2009. J Bone Miner Res. 24: 162-7. PMID: 18715141
8. A single-center experience in 20 patients with infantile malignant osteopetrosis.  |  Mazzolari, E., et al. 2009. Am J Hematol. 84: 473-9. PMID: 19507210

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TCIRG1 Antibody (6H3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TCIRG1 Antibody (6H3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TCIRG1 Antibody (6H3) Specifications

Alternate Product Name: TCIRG1

Product Clone Name: 6H3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 121-220

Epitope Target: TCIRG1

Epitope Species: human

Product Reactivity/Detection: TCIRG1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TCIRG1 Antibody (6H3): N/A