TCF7L2/TCF4 Antibody (F-7): sc-271288
- TCF7L2/TCF4 Antibody (F-7) is a mouse monoclonal IgG3 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 565-592 at the C-terminus of TCF-4 of human origin
- recommended for detection of TCF-4 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-271288 X, 200 µg/0.1 ml)
- See TCF7L2/TCF4 (D-4): sc-166699 for TCF7L2/TCF4 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG3 BP-HRP is the preferred secondary detection reagent for TCF7L2/TCF4 Antibody (F-7) for WB applications. This reagent is now offered in a bundle with TCF7L2/TCF4 Antibody (F-7) (see ordering information below).
TCF-4 Antibody (F-7) is a mouse monoclonal IgG3 antibody that detects TCF-4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCF-4, a member of the T cell factor family, plays a crucial role in lymphoid cell development and is a key transcriptional activator in the Wnt signaling pathway. TCF-4 is primarily located in the cytoplasm, where TCF-4 forms a complex with β-catenin before translocating to the nucleus, a process that is vital for the regulation of Wnt target genes, many of which are associated with cancer. The interaction between TCF-4 and β-catenin is essential for the transcriptional activation of these genes, and the presence of the high mobility group (HMG) 1 box motif in TCF-4 facilitates DNA binding. Additionally, TCF-4′s interaction with c-Jun, which is modulated by phosphorylation, highlights TCF-4′s role in integrating various signaling pathways that influence intestinal tumorigenesis. Beyond implications in cancer, TCF-4 has also been linked to bipolar affective disorder, underscoring TCF-4′s importance in both developmental and pathological processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCF7L2/TCF4 Antibody (F-7) | sc-271288 | 200 µg/ml | $316.00 | |||
TCF7L2/TCF4 Antibody (F-7): m-IgG3 BP-HRP Bundle | sc-550402 | 200 µg Ab; 40 µg BP | $354.00 | |||
TCF7L2/TCF4 (F-7) Neutralizing Peptide | sc-271288 P | 100 µg/0.5 ml | $68.00 | |||
TCF7L2/TCF4 Antibody (F-7) X | sc-271288 X | 200 µg/0.1 ml | $316.00 |