Date published: 2026-4-24

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TC-I 15 (CAS 916734-43-5)

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Alternate Names:
N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine
CAS Number:
916734-43-5
Molecular Weight:
520.62
Molecular Formula:
C23H28N4O6S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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TC-I 15 is a compound that has attention in biochemical research due to its inhibitory action on integrin α2β1, a receptor involved in cell adhesion and signaling processes. This particular integrin is important in the mediation of cell-extracellular matrix interactions, and its inhibition by TC-I 15 allows scientists to study the pathways that regulate cell adhesion, migration, and differentiation. By modulating integrin α2β1, TC-I 15 helps to elucidate its role in angiogenesis and tumor metastasis, providing insights into the underlying mechanisms of cancer progression. Additionally, TC-I 15 is instrumental in research focused on fibrosis and thrombosis, where integrin α2β1 is known to play a role. The compound′s ability to selectively inhibit integrin α2β1 makes it an essential tool for advancing the comprehension of integrin-mediated signaling and its implications in various biological applications.


TC-I 15 (CAS 916734-43-5) References

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  2. MUC5B mucin production is upregulated by fibronectin and laminin in human lung epithelial cells via the integrin and ERK dependent pathway.  |  Ito, Y., et al. 2015. Biosci Biotechnol Biochem. 79: 1794-801. PMID: 26057585
  3. Cells Sensing Mechanical Cues: Stiffness Influences the Lifetime of Cell-Extracellular Matrix Interactions by Affecting the Loading Rate.  |  Jiang, L., et al. 2016. ACS Nano. 10: 207-17. PMID: 26701367
  4. High Throughput Label Free Measurement of Cancer Cell Adhesion Kinetics Under Hemodynamic Flow.  |  Spencer, A. and Baker, AB. 2016. Sci Rep. 6: 19854. PMID: 26816215
  5. Extracellular vesicles of carcinoma-associated fibroblasts creates a pre-metastatic niche in the lung through activating fibroblasts.  |  Kong, J., et al. 2019. Mol Cancer. 18: 175. PMID: 31796058
  6. Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis.  |  Huang, YL., et al. 2020. Elife. 9: PMID: 33026975
  7. The stiffness-controlled release of interleukin-6 by cardiac fibroblasts is dependent on integrin α2β1.  |  Gałdyszyńska, M., et al. 2020. J Cell Mol Med. 24: 13853-13862. PMID: 33124775
  8. Muscle-Derived Lumican Stimulates Bone Formation via Integrin α2β1 and the Downstream ERK Signal.  |  Lee, JY., et al. 2020. Front Cell Dev Biol. 8: 565826. PMID: 33240876
  9. Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin.  |  Hunter, EJ., et al. 2021. Toxicol Appl Pharmacol. 428: 115669. PMID: 34363821
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

TC-I 15, 10 mg

sc-474353
10 mg
$364.00