CD138/SDC1/Syndecan-1 Antibody (SB55a): sc-69833

Syndecan-1 Antibody (SB55a) is a mouse monoclonal IgG2a antibody that detects Syndecan-1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Syndecan-1, also known as CD138, is a type I integral membrane proteoglycan that plays a crucial role in cell signaling and adhesion by interacting with components of the extracellular matrix, such as collagens, fibronectin, and thrombospondin. This interaction is vital for maintaining tissue architecture and facilitating cellular communication, particularly in the immune system where Syndecan-1 is expressed on pre-B cells, immature B cells, and plasma cells. Additionally, Syndecan-1 is localized on the basolateral surfaces of epithelial cells and endothelial cells of sprouting capillaries, highlighting Syndecan-1′s importance in vascular development and tissue repair. Syndecan-1′s ability to co-localize with actin-rich filaments suggests a role as a link between the cytoskeleton and the extracellular matrix, thereby influencing cellular morphology and motility. Anti-Syndecan-1 antibody (SB55a) is an essential tool for researchers studying the dynamics of cell adhesion and signaling pathways in various biological contexts.

The preferred CD138/SDC1/Syndecan-1 antibody is CD138/SDC1/Syndecan-1 Antibody (DL-101): sc-12765.