CD138/SDC1/Syndecan-1 Antibody (B-A38): sc-65337

Syndecan-1 Antibody (B-A38) is a mouse monoclonal IgG1 antibody that detects Syndecan-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Syndecan-1, also known as CD138, is a type I integral membrane proteoglycan that plays a crucial role in cell signaling and adhesion by serving as a receptor for the extracellular matrix. Syndecan-1 (B-A38) antibody recognizes pre-B cells, immature B cells, and plasma cells, highlighting Syndecan-1′s importance in the immune response, while localization on basolateral surfaces of epithelial cells and endothelial cells of sprouting capillaries underscores Syndecan-1′s role in tissue organization and vascular development. Syndecan-1 interacts with various extracellular matrix components, including collagens, fibronectin, and thrombospondin, facilitating cell-matrix interactions that are essential for maintaining tissue architecture and promoting cellular communication. Syndecan-1′s co-localization with actin-rich filaments suggests a link between the cytoskeleton and extracellular matrix, thereby influencing cellular shape and motility. Anti-Syndecan-1 antibody (B-A38) serves as an invaluable tool for researchers investigating the dynamics of cell adhesion and signaling pathways in various biological contexts.

The preferred CD138/SDC1/Syndecan-1 antibody is CD138/SDC1/Syndecan-1 Antibody (DL-101): sc-12765.