Molecular structure of Sulprostone, CAS Number: 60325-46-4
Sulprostone (CAS 60325-46-4)
See product citations (8)
Application:
Sulprostone is a metabolism resistant synthetic analog of PGE2 that is a selective EP3 prostanoid receptor agonist
CAS Number:
60325-46-4
Purity:
>98%
Molecular Weight:
465.6
Molecular Formula:
C23H31NO7S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sulprostone is an analogue of prostaglandin E2 that functions as a potent uterotonic agent. It acts by binding to and activating the prostaglandin E2 receptor, leading to the stimulation of smooth muscle contractions in the uterus. This chemical′s mode of action involves the activation of adenylate cyclase, which results in an increase in intracellular cyclic adenosine monophosphate (cAMP) levels. Elevated cAMP levels leads to the relaxation of uterine smooth muscle and the induction of rhythmic contractions. Sulprostone may inhibit the production of inflammatory mediators and modulate the immune response in certain experimental applications. Its ability to influence uterine contractions and modulate immune responses may be useful for investigating various physiological and pathological processes in experimental models.
Sulprostone (CAS 60325-46-4) References
- The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. | Abramovitz, M., et al. 2000. Biochim Biophys Acta. 1483: 285-93. PMID: 10634944
- Prostaglandin regulation of gastric slow waves and peristalsis. | Forrest, AS., et al. 2009. Am J Physiol Gastrointest Liver Physiol. 296: G1180-90. PMID: 19359421
- Prostaglandins compromise basal forebrain cholinergic neuron differentiation and survival: action at EP1/3 receptors results in AIF-induced death. | Jonakait, GM. and Ni, L. 2009. Brain Res. 1285: 30-41. PMID: 19555672
- Intermolecular cross-talk between the prostaglandin E2 receptor (EP)3 of subtype and thromboxane A(2) receptor signalling in human erythroleukaemic cells. | Reid, HM. and Kinsella, BT. 2009. Br J Pharmacol. 158: 830-47. PMID: 19702786
- E Prostanoid-1 receptor regulates renal medullary alphaENaC in rats infused with angiotensin II. | González, AA., et al. 2009. Biochem Biophys Res Commun. 389: 372-7. PMID: 19732740
- Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency. | Lang, PA., et al. 2009. Cell Physiol Biochem. 24: 415-28. PMID: 19910682
- Characterisation of the prostanoid receptor mediating inhibition of smooth muscle contractility in the rat prostate gland. | Tokanovic, S., et al. 2010. Naunyn Schmiedebergs Arch Pharmacol. 381: 321-8. PMID: 20180098
- Receptor binding in various tissues of PGE2, PGF2 alpha and sulprostone, a novel PGE2-derivative. | Schillinger, E., et al. 1979. Prostaglandins. 18: 292-302. PMID: 230545
- Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches. | Lu, Z., et al. 2020. Front Physiol. 11: 583082. PMID: 33488391
- Hyperpolarization-activated cyclic nucleotide-gated channels working as pacemaker channels in colonic interstitial cells of Cajal. | Choi, S., et al. 2022. J Cell Mol Med. 26: 364-374. PMID: 34845842
- Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss. | Ye, Y., et al. 2022. Biol Reprod. 106: 910-918. PMID: 35134851
- Stimulation of the EP3 receptor causes lung oedema by activation of TRPC6 in pulmonary endothelial cells. | Jiang, T., et al. 2022. Eur Respir J. 60: PMID: 35450969
- Termination of pregnancy in the second trimester - the course of different therapy regimens. | Franke, JF., et al. 2022. J Perinat Med. 50: 1053-1060. PMID: 35532780
- TEI-3356, a highly selective agonist for the prostaglandin EP3 receptor. | Negishi, M., et al. 1994. Prostaglandins. 48: 275-83. PMID: 7855308
- Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. | Boie, Y., et al. 1997. Eur J Pharmacol. 340: 227-41. PMID: 9537820
Inhibitor of:
EP3.Activator of:
BRAK, DP, EP1, EP2, EP3, EP4, FOXP1, GPR-44, GPR22, MIP-1b, PGE synthase, PGF2alphaR, and PGI2 synthase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sulprostone, 1 mg | sc-201348 | 1 mg | $206.00 | |||
Sulprostone, 5 mg | sc-201348A | 5 mg | $592.00 |