Sulfo-Cy3-Tetrazine (CAS 1801924-47-9)
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Sulfo-Cy3-Tetrazine is widely utilized in bioconjugation and imaging applications. Its fluorescence properties, conferred by the Cy3 dye, enable the visualization and detection of biomolecules in biological samples. The tetrazine moiety exhibits exceptional reactivity with trans-cyclooctene (TCO) and other strained alkenes through a rapid and bioorthogonal reaction known as the inverse-electron-demand Diels-Alder (IEDDA) reaction. This reaction forms a stable covalent bond, allowing precise labeling and tracking of target molecules. Furthermore, the addition of the sulfonic acid group enhances the water solubility of Sulfo-Cy3-Tetrazine, making it compatible with aqueous environments encountered in biological systems. This attribute facilitates its application in live cell imaging, in vivo studies, and other biological assays.
Sulfo-Cy3-Tetrazine (CAS 1801924-47-9) References
- Rapid labeling of metabolically engineered cell-surface glycoconjugates with a carbamate-linked cyclopropene reporter. | Späte, AK., et al. 2014. Bioconjug Chem. 25: 147-54. PMID: 24328258
- Expanding the scope of cyclopropene reporters for the detection of metabolically engineered glycoproteins by Diels-Alder reactions. | Späte, AK., et al. 2014. Beilstein J Org Chem. 10: 2235-42. PMID: 25298790
- Cyclopropenes: a new tool for the study of biological systems | João M. J. M. Ravasco,a Carlos M. Monteiroa and Alexandre F. Trindade *a. 2017. Org. Chem. Front. 4: 1167-1198.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sulfo-Cy3-Tetrazine, 1 mg | sc-499255 | 1 mg | $250.00 |