Sulfamoyl Chloride (CAS 7778-42-9)

Sulfamoyl chloride, a white crystalline solid with high solubility in water, is an organosulfur compound with versatile applications. This compound serves as a valuable reagent in numerous synthetic transformations, enabling the synthesis of sulfonamides, sulfonamidines, and sulfonyl chlorides. Moreover, it plays a role in the production of specific pharmaceuticals, dyes, and other organic compounds. Sulfamoyl chloride finds utility in synthesizing heterocyclic compounds like thiazoles and oxazoles, as well as in the preparation of polymers and other organic materials. Additionally, it exhibits catalytic properties in organic reactions such as the Michael addition and the Wittig reaction. While the complete mechanism of action of sulfamoyl chloride remains unclear, it is believed that the reaction involves the sulfur dioxide molecule reacting with the chlorinating agent to form a sulfonyl chloride intermediate. Subsequently, this intermediate engages with an amine or alcohol to yield a sulfonamide or sulfonyl chloride, respectively.