Date published: 2026-2-19

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Sulfamonomethoxine (CAS 1220-83-3)

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Application:
Sulfamonomethoxine is an enzyme inhibitor used to address hyperpyrexia
CAS Number:
1220-83-3
Molecular Weight:
280.30
Molecular Formula:
C11H12N4O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sulfamonomethoxine, also referred to as Sulfamethoxazole, is an sulfonamide class. Sulfamonomethoxine is a synthetic compound that has gained widespread recognition. With its broad-spectrum properties, it exhibits effectiveness against a wide array of Gram-positive and Gram-negative bacteria. The mechanism of action underlying sulfamonomethoxine involves impeding bacterial cell wall synthesis. By binding to a specific enzyme within the bacterial cell wall, it inhibits the production of new cell wall components. Consequently, the bacteria are unable to generate new cell walls, leading to their demise.


Sulfamonomethoxine (CAS 1220-83-3) References

  1. Determining sulfamonomethoxine and its acetyl/hydroxyl metabolites in chicken plasma under organic solvent-free conditions.  |  Furusawa, N. 2006. Anal Bioanal Chem. 385: 1570-4. PMID: 16838157
  2. Degradation of sulfamonomethoxine with Fe3O4 magnetic nanoparticles as heterogeneous activator of persulfate.  |  Yan, J., et al. 2011. J Hazard Mater. 186: 1398-404. PMID: 21237557
  3. Pharmacokinetics of sulfamonomethoxine in tongue sole (Cynoglossus semilaevis) after intravenous and oral administration.  |  Chang, ZQ., et al. 2014. Fish Physiol Biochem. 40: 1275-9. PMID: 24577641
  4. Toxicity of the veterinary sulfonamide antibiotic sulfamonomethoxine to five aquatic organisms.  |  Huang, DJ., et al. 2014. Environ Toxicol Pharmacol. 38: 874-80. PMID: 25461547
  5. Distribution of sulfamonomethoxine and trimethoprim in egg yolk and white.  |  Bilandžić, N., et al. 2015. Food Chem. 178: 32-7. PMID: 25704680
  6. Perinatal sulfamonomethoxine exposure influences physiological and behavioral responses and the brain mTOR pathway in mouse offspring.  |  Zhang, Q., et al. 2017. Hum Exp Toxicol. 36: 256-275. PMID: 27164927
  7. Removal behaviors of sulfamonomethoxine and its degradation intermediates in fresh aquaculture wastewater using zeolite/TiO2 composites.  |  Nomura, Y., et al. 2017. J Hazard Mater. 340: 427-434. PMID: 28750362
  8. Using ionic liquid monomer to improve the selective recognition performance of surface imprinted polymer for sulfamonomethoxine in strong polar medium.  |  Zhu, G., et al. 2019. J Chromatogr A. 1592: 38-46. PMID: 30709623
  9. The effect of sulfamonomethoxine treatment on the gut microbiota of Nile tilapia (Oreochromis niloticus).  |  Ming, J., et al. 2020. Microbiologyopen. 9: e1116. PMID: 32965800
  10. Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia.  |  Niu, Y., et al. 2021. Hepatology. 74: 1461-1479. PMID: 33813748
  11. Photocatalytic degradation of sulfamonomethoxine by mesoporous phosphorus-doped titania under simulated solar light irradiation.  |  Li, J., et al. 2021. Chemosphere. 285: 131553. PMID: 34271470
  12. Degradation of sulfamonomethoxine in solution using pulsed plasma discharge - identification of by-products and toxicity of treated solution to green algae.  |  Ishikawa, NK., et al. 2022. Water Sci Technol. 86: 2430-2440. PMID: 36378190
  13. Biotransformation of sulfamonomethoxine in a granular sludge system: Pathways and mechanisms.  |  Li, MY., et al. 2023. Chemosphere. 313: 137508. PMID: 36493889
  14. The structure of the glucuronide of sulphadimethoxine formed in man.  |  Bridges, JW., et al. 1965. Biochem J. 96: 829-36. PMID: 5862422
  15. Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs.  |  Hong, YL., et al. 1995. Antimicrob Agents Chemother. 39: 1756-63. PMID: 7486915

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sulfamonomethoxine, 10 mg

sc-220163
10 mg
$270.00