Sulfadimethoxine (CAS 122-11-2)
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Sulfadimethoxine is a sulfonamide antibiotic that is active against Gram-negative and Gram-positive bacteria and other microorganisms. It inhibits recombinant P. carinii dihydropteroate synthase (DHPS IC50 = 25 nM), an enzyme required for folate biosynthesis, in a cell-free assay. It does this by competing with para-aminobenzoic acid (PABA) for the binding site on dihydropteroate synthase. Sulfadimethoxine is active against S. aureus, S. pneumoniae, K. pneumoniae, and E. coli in a disc assay. It is also active against C. spiroforme isolates from rabbits (MIC90 = 256 μg/ml) and certain M. bovoculi isolates from keratoconjunctivitis infections in cows (MIC50 = ≤256 μg/ml). Sulfadimethoxine is efficacious against S. pneumoniae, K. pneumoniae, and E. coli systemic infections in mice with 50% curative dose (CD50) values of 79.7, 2.7, and 12.2 mg/kg, respectively. It is also efficacious against H. capsulatum systemic fungal infections in mice (CD50 = 300 mg/kg).
Sulfadimethoxine (CAS 122-11-2) References
- Sulfadimethoxine degradation kinetics in manure as affected by initial concentration, moisture, and temperature. | Wang, QQ., et al. 2006. J Environ Qual. 35: 2162-9. PMID: 17071885
- Sulfadimethoxine and sulfaguanidine: their sorption potential on natural soils. | Białk-Bielińska, A., et al. 2012. Chemosphere. 86: 1059-65. PMID: 22197018
- Removal of sulfadimethoxine in soil mediated by extracellular oxidoreductases. | Singh, R., et al. 2015. Environ Sci Pollut Res Int. 22: 16868-74. PMID: 26104901
- Sulfadimethoxine transport in soil columns in relation to sorbable and non-sorbable tracers. | Park, JY. and Huwe, B. 2016. Environ Sci Pollut Res Int. 23: 12456-66. PMID: 26983917
- Sulfadimethoxine in giant freshwater prawns (Macrobrachium rosenbergii): an attempt to estimate the withdrawal time by a population pharmacokinetic approach. | Poapolathep, A., et al. 2017. J Vet Pharmacol Ther. 40: 476-485. PMID: 27925222
- Label-Free Fluorescence-Based Aptasensor for the Detection of Sulfadimethoxine in Water and Fish. | Chen, XX., et al. 2019. Appl Spectrosc. 73: 294-303. PMID: 30838894
- Electrochemical aptasensor for sulfadimethoxine detection based on the triggered cleavage activity of nuclease P1 by aptamer-target complex. | Bai, Z., et al. 2019. Talanta. 204: 409-414. PMID: 31357313
- Determination of sulfadimethoxine in milk with aptamer-functionalized Fe3 O4 /graphene oxide as magnetic solid-phase extraction adsorbent prior to HPLC. | Guo, Y., et al. 2020. J Sep Sci. 43: 3499-3508. PMID: 32573934
- Insights into enhanced biodegradation of sulfadimethoxine by catalyst: Transcriptomic responses and free radical interactions. | Zhang, L., et al. 2021. Sci Total Environ. 774: 145641. PMID: 33609830
- Tetracycline, sulfadimethoxine, and antibiotic resistance gene dynamics during anaerobic digestion of dairy manure. | Schueler, J., et al. 2021. J Environ Qual. 50: 694-705. PMID: 33955027
- Sorption studies of sulfadimethoxine and tetracycline molecules on β-antimonene nanotube - A first-principles insight. | Nagarajan, V. and Chandiramouli, R. 2021. J Mol Graph Model. 108: 107988. PMID: 34325354
- Microfluidic flow-injection aptamer-based chemiluminescence platform for sulfadimethoxine detection. | Wang, Y., et al. 2022. Mikrochim Acta. 189: 117. PMID: 35195801
- Effect of sulfadimethoxine on thiopental distribution and elimination in rats. | Yu, HY., et al. 1981. J Pharm Sci. 70: 323-6. PMID: 7264902
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sulfadimethoxine, 5 g | sc-212972 | 5 g | $119.00 |