Molecular structure of SU9516, CAS Number: 666837-93-0
SU9516 (CAS 666837-93-0)
See product citations (4)
Alternate Names:
(Z)-3-((1H-imidazol-5-yl)methylene)-5-methoxyindolin-2-one
Application:
SU9516 is a selectively potent ATP-competitive inhibitor of CDKs
CAS Number:
666837-93-0
Molecular Weight:
241.25
Molecular Formula:
C13H11N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SU9516 is a 3-substituted indolinone compound displaying anti-proliferative and proapoptotic properties in tumor cells. SU9516 displays activity as a selectively potent ATP-competitive inhibitor of CDKs. It also shows no significant effect (IC50 >10 µM) on the activities of PKC, p38, PDGFRβ, or EGFR. SU9516 has an Inhibitory effect on proliferation of growth-factor stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F.
SU9516 (CAS 666837-93-0) References
- A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells. | Lane, ME., et al. 2001. Cancer Res. 61: 6170-7. PMID: 11507069
- SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells. | Yu, B., et al. 2002. Biochem Pharmacol. 64: 1091-100. PMID: 12234612
- SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2. | Moshinsky, DJ., et al. 2003. Biochem Biophys Res Commun. 310: 1026-31. PMID: 14550307
- CDK inhibitor enhances the sensitivity to 5-fluorouracil in colorectal cancer cells. | Takagi, K., et al. 2008. Int J Oncol. 32: 1105-10. PMID: 18425338
- Cyclin-dependent kinase inhibitor SU9516 enhances sensitivity to methotrexate in human T-cell leukemia Jurkat cells. | Uchiyama, H., et al. 2010. Cancer Sci. 101: 728-34. PMID: 20059476
- A Novel High-Throughput 3D Screening System for EMT Inhibitors: A Pilot Screening Discovered the EMT Inhibitory Activity of CDK2 Inhibitor SU9516. | Arai, K., et al. 2016. PLoS One. 11: e0162394. PMID: 27622654
- CDK inhibitor SU9516 induces tetraploid blastocyst formation from parthenogenetically activated porcine embryos. | Guo, Q., et al. 2017. Biotechnol Lett. 39: 951-957. PMID: 28315059
- SU9516 Increases α7β1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy. | Sarathy, A., et al. 2017. Mol Ther. 25: 1395-1407. PMID: 28391962
- Cyclin-dependent kinase 2 inhibitor SU9516 increases sensitivity of colorectal carcinoma cells Caco-2 but not HT29 to BH3 mimetic ABT-737. | Štefaniková, A., et al. 2017. Gen Physiol Biophys. 36: 539-547. PMID: 29372687
- Development of a Chemical Cocktail That Rescues Mouse Brain Demyelination in a Cuprizone-Induced Model. | Lai, PL., et al. 2022. Cells. 11: PMID: 35406658
Inhibitor of:
Cdc2, Cdk2, and Cdk4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SU9516, 5 mg | sc-204905 | 5 mg | $149.00 |