Date published: 2025-9-5

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Stearic anhydride (CAS 638-08-4)

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Alternate Names:
Octadecanoic anhydride
CAS Number:
638-08-4
Molecular Weight:
550.94
Molecular Formula:
C36H70O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Stearic anhydride, a fatty acid derivative, has emerged as a notable compound in scientific research, particularly in the fields of materials science and organic synthesis. Its chemical structure comprises a stearic acid molecule without the hydroxyl group, resulting in an anhydrous form. In research, stearic anhydride serves as a versatile reagent for the modification of surfaces and the synthesis of various organic compounds. One notable research application involves its use as a surface modifier in nanoparticle synthesis. Through chemisorption onto nanoparticle surfaces, stearic anhydride can impart hydrophobicity and stability to nanoparticles, facilitating their dispersion in non-polar solvents and preventing aggregation. Additionally, stearic anhydride finds utility as a building block in organic synthesis, particularly in the formation of esters and amides. Its reactivity with nucleophiles enables the synthesis of stearate esters, which are valuable in the production of surfactants, lubricants, and emulsifiers. Moreover, stearic anhydride has been employed in the preparation of stearoyl derivatives for use in drug delivery systems and biomaterials. Ongoing research continues to explore the diverse synthetic applications of stearic anhydride, highlighting its significance as a versatile building block in chemical synthesis and materials science.


Stearic anhydride (CAS 638-08-4) References

  1. Layer-by-layer surface modification of lipid nanocapsules.  |  Hirsjärvi, S., et al. 2010. Eur J Pharm Biopharm. 76: 200-7. PMID: 20656028
  2. Stearic acid esterified pectin: Preparation, characterization, and application in edible hydrophobic pectin/chitosan composite films.  |  Wang, P., et al. 2021. Int J Biol Macromol. 186: 528-534. PMID: 34116093
  3. Effects of a new compatibilizer system on the flexural properties of wood–polyethylene composites  |  Geng Y, Li K, Simonsen J. 2004. Journal of Applied Polymer Science. 9: 3667-3672.
  4. Layered structures of hydrophobically modified chitosan derivatives  |  Wu Y, Seo T, Sasaki T, et al. 2006. Carbohydrate polymers. 63: 493-499.
  5. Further investigation of polyaminoamide‐epichlorohydrin/stearic anhydride compatibilizer system for wood‐polyethylene composites  |  Geng Y, Li K, Simonsen J. 2006. Journal of applied polymer science. 99: 712-718.
  6. The role of vapour deposition in the hydrophobization treatment of cellulose fibres using alkyl ketene dimers and alkenyl succinic acid anhydrides  |  Zhang H, Kannangara D, Hilder M, et al. 2007. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 297: 203-210.
  7. Tunable Amphiphilic Poly (Ether‐Anhydride) Gel Nanoparticles for the Delivery of Hydrophobic Drugs  |  Wang Z, Cai Z, Guo Q. 2010. Macromolecular Symposia. Weinheim. 297: 167-178.
  8. Value‐added derivatives of soda lignin from alfa grass (Stipa tenacissima). I. Modification and characterization  |  Nadji H, Bedard Y, Benaboura A, et al. 2010. Journal of applied polymer science. 115: 1546-1554.
  9. Selective deoxygenation of stearic acid via an anhydride pathway  |  Hollak S A W, Bitter J H, van Haveren J, et al. 2012. RSC advances. 2: 9387-9391.
  10. Synthesis and characterization of a supported Pd complex on carbon nanofibers for the selective decarbonylation of stearic acid to 1-heptadecene: the importance of subnanometric Pd dispersion  |  Ochoa E, Henao W, Fuertes S, et al. 2020. Catalysis Science & Technology. 10: 2970-2985.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Stearic anhydride, 50 g

sc-215904
50 g
$352.00

Stearic anhydride, 100 g

sc-215904A
100 g
$660.00