STAU2 Antibody (S-35): sc-101144

STAU2 Antibody (S-35) is a mouse monoclonal IgG1 kappa light chain antibody that detects STAU2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-STAU2 antibody (S-35) is available as a non-conjugated format. STAU2, also known as staufen, RNA binding protein, homolog 2, or 39K2/39K3, plays a crucial role in the transport and localization of mRNA within neurons, which is vital for proper neuronal function and development. STAU2 is predominantly expressed in brain tissue and is involved in the microtubule-dependent delivery of neuronal RNA to dendrites, thereby influencing synaptic plasticity and the formation of dendritic spines. STAU2 belongs to the double-stranded RNA-binding protein family and shuttles between the nucleus and cytoplasm, where STAU2 associates with ribonucleoprotein particles that facilitate mRNA transport. Notably, interference with STAU2 expression in mature neurons results in a significant reduction in dendritic spines, underscoring STAU2′s essential role in maintaining synaptic structure and function. STAU2 exists in five different isoforms due to alternative splicing, which may contribute to diverse functional roles in neuronal development and plasticity.

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STAU2 Antibody (S-35) References:

1. Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles.  |  Duchaîne, TF., et al. 2002. J Cell Sci. 115: 3285-95. PMID: 12140260
2. The brain-specific double-stranded RNA-binding protein Staufen2: nucleolar accumulation and isoform-specific exportin-5-dependent export.  |  Macchi, P., et al. 2004. J Biol Chem. 279: 31440-4. PMID: 15166236
3. Alternative splicing of Staufen2 creates the nuclear export signal for CRM1 (Exportin 1).  |  Miki, T. and Yoneda, Y. 2004. J Biol Chem. 279: 47473-9. PMID: 15364930
4. Staufen recruitment into stress granules does not affect early mRNA transport in oligodendrocytes.  |  Thomas, MG., et al. 2005. Mol Biol Cell. 16: 405-20. PMID: 15525674
5. The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons.  |  Monshausen, M., et al. 2004. Neuromolecular Med. 6: 127-44. PMID: 15970630
6. The zinc-finger protein ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons.  |  Elvira, G., et al. 2006. J Neurochem. 96: 105-17. PMID: 16277607
7. The role of mammalian Staufen on mRNA traffic: a view from its nucleocytoplasmic shuttling function.  |  Miki, T., et al. 2005. Cell Struct Funct. 30: 51-6. PMID: 16377940
8. The brain-specific double-stranded RNA-binding protein Staufen2 is required for dendritic spine morphogenesis.  |  Goetze, B., et al. 2006. J Cell Biol. 172: 221-31. PMID: 16418534

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-STAU2 Antibody (S-35) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-STAU2 Antibody (S-35) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

STAU2 Antibody (S-35) Specifications

Alternate Product Name: STAU2

Product Clone Name: S-35

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-91

Epitope Target: STAU2

Epitope Species: human

Product Reactivity/Detection: STAU2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for STAU2 Antibody (S-35): N/A