Molecular structure of Sp-5,6-DCI-cBiMPS, CAS Number: 120912-54-1
Sp-5,6-DCI-cBiMPS (CAS 120912-54-1)
See product citations (5)
Application:
Sp-5,6-DCI-cBiMPS is potent activator of PKA
CAS Number:
120912-54-1
Purity:
≥98%
Molecular Weight:
419.2
Molecular Formula:
C12H10Cl2N2O5PS•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sp-5,6-DCI-cBiMPS is a phosphodiesterase-sensitive cAMP analog and potent activator of PKA (cAMP-dependent protein kinase). It has been tested to be cell permeable and resists hydrolysis from type I, II, and III phosphodiesterases. Observed to stop the aggregation induced by thrombin and initiated protein phosphorylation induced by prostaglandin E1 in human platelets. When applied extracellulary to T84 human colon cancer cells in vitro, Sp-5,6-DCI-cBiMPS was shown to be a potent activator of Cl- secretion. Practical in experiments distinguishing between cAMP and cGMP signal transduction pathways.
Sp-5,6-DCI-cBiMPS (CAS 120912-54-1) References
- CREB phosphorylation and melatonin biosynthesis in the rat pineal gland: involvement of cyclic AMP dependent protein kinase type II. | Maronde, E., et al. 1999. J Pineal Res. 27: 170-82. PMID: 10535767
- Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP. | Gambaryan, S., et al. 2006. Am J Physiol Endocrinol Metab. 290: E423-33. PMID: 16219670
- Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. | Sandberg, M., et al. 1991. Biochem J. 279 (Pt 2): 521-7. PMID: 1659381
- [Urocortin decreases phosphorylation of MYPT1 and increases the myosin phosphatase activity via elevation of the intracellular level of cAMP]. | Lubomirov, LT., et al. 2006. Biofizika. 51: 773-80. PMID: 17131811
- cAMP pulsing of denuded mouse oocytes increases meiotic resumption via activation of AMP-activated protein kinase. | Chen, J., et al. 2009. Reproduction. 138: 759-70. PMID: 19700529
- Expression of full-length human procathepsin L cDNA in Escherichia coli and refolding of the expression product. | Dolinar, M., et al. 1995. Biol Chem Hoppe Seyler. 376: 385-8. PMID: 7576233
- Dephosphorylation of the focal adhesion protein VASP in vitro and in intact human platelets. | Abel, K., et al. 1995. FEBS Lett. 370: 184-8. PMID: 7656973
- (Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor. | Butt, E., et al. 1994. Eur J Pharmacol. 269: 265-8. PMID: 7851503
- Membrane-permeant derivatives of cyclic AMP optimized for high potency, prolonged activity, or rapid reversibility. | Schultz, C., et al. 1994. Mol Pharmacol. 46: 702-8. PMID: 7969049
- Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-cyclic monophosphorothioate is a potent stimulus for insulin release. | Laychock, SG. 1993. Endocr Res. 19: 113-22. PMID: 8287829
- Iloprost activates KCa channels of vascular smooth muscle cells: role of cAMP-dependent protein kinase. | Schubert, R., et al. 1996. Am J Physiol. 271: C1203-11. PMID: 8897826
- Effects of activation and inhibition of cAMP-dependent protein kinase on long-term habituation in the crab Chasmagnathus. | Romano, A., et al. 1996. Brain Res. 735: 131-40. PMID: 8905178
- Iloprost dilates rat small arteries: role of K(ATP)- and K(Ca)-channel activation by cAMP-dependent protein kinase. | Schubert, R., et al. 1997. Am J Physiol. 272: H1147-56. PMID: 9087587
Activator of:
PKA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sp-5,6-DCI-cBiMPS, 1 mg | sc-201566 | 1 mg | $244.00 |