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Sodium cyanate (CAS 917-61-3)

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Alternate Names:
Sodium isocyanate
Application:
Sodium cyanate is an ideal nucleophile
CAS Number:
917-61-3
Purity:
≥95%
Molecular Weight:
65.01
Molecular Formula:
NaOCN
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sodium cyanate is a chemical compound that functions as a precursor in the synthesis of various organic compounds. It acts as a nucleophile in reactions with electrophiles, leading to the formation of ureas and other nitrogen-containing compounds. Sodium cyanate participates in the isocyanate formation process, where it reacts with alcohols or amines to produce carbamates and urethanes. Sodium Cyanate′s mechanism of action involves its ability to undergo nucleophilic substitution reactions, enabling the formation of diverse organic molecules. Sodium cyanate′s reactivity with different functional groups allows for the creation of complex structures, making it a versatile building block in organic synthesis.


Sodium cyanate (CAS 917-61-3) References

  1. Sodium cyanate alters glutathione homeostasis in rodent brain: relationship to neurodegenerative diseases in protein-deficient malnourished populations in Africa.  |  Tor-Agbidye, J., et al. 1999. Brain Res. 820: 12-9. PMID: 10023026
  2. Toxic-therapeutic ratio of sodium cyanate.  |  Charache, S., et al. 1975. Arch Intern Med. 135: 1043-7. PMID: 1156065
  3. Sodium cyanate-induced opening of calcium-activated potassium currents in hippocampal neuron-derived H19-7 cells.  |  Huang, CW., et al. 2005. Neurosci Lett. 377: 110-4. PMID: 15740847
  4. Bis(cyanato-κN)tetra-kis-(2,6-dimethyl-pyrazine-κN(4))nickel(II).  |  Wöhlert, S., et al. 2012. Acta Crystallogr Sect E Struct Rep Online. 68: m970. PMID: 22807789
  5. pH-related effects of sodium cyanate on macromolecular synthesis and tumor cell division.  |  Hu, JJ., et al. 1988. Biochem Pharmacol. 37: 2259-66. PMID: 2454112
  6. A novel strategy for the efficient decomposition of toxic sodium cyanate by hematite.  |  Dong, K., et al. 2020. Chemosphere. 256: 127047. PMID: 32446000
  7. Synthesis of 3H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate.  |  Du, S., et al. 2021. Org Lett. 23: 2359-2363. PMID: 33691408
  8. Atroposelective Three-Component Coupling of Cyclic Diaryliodoniums and Sodium Cyanate Enabled by the Dual-Role of Phenol.  |  Yang, S., et al. 2023. Angew Chem Int Ed Engl. 62: e202302749. PMID: 36947004
  9. Effects of sodium cyanate in mice bearing B16 melanoma.  |  Lea, MA., et al. 1986. Cancer Chemother Pharmacol. 17: 231-5. PMID: 3742708
  10. Sodium cyanate: chemical properties relevant to sickle cell disease therapy.  |  Labbe, RF. 1973. J Pharm Sci. 62: 1727-9. PMID: 4752126
  11. Sodium cyanate as a potential treatment for sickle-cell disease.  |  Gillette, PN., et al. 1974. N Engl J Med. 290: 654-60. PMID: 4813727
  12. Effect of sodium cyanate upon the function of normal human polymorphonuclaer leukocytes.  |  Ratzan, KR., et al. 1975. J Infect Dis. 131 Suppl: S73-80. PMID: 805192
  13. Alteration of the systemic antitumor activity of melphalan by sodium cyanate in MOPC-460D myeloma-bearing BALB/c mice.  |  Shenouda, G., et al. 1993. J Surg Oncol. 52: 110-4. PMID: 8468973
  14. Sodium cyanate: from a promising therapeutic agent to a research tool in high altitude physiology.  |  Rivera-Ch, M., et al. 1996. Biol Res. 29: 167-76. PMID: 9278706

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sodium cyanate, 5 g

sc-236899
5 g
$31.00

Sodium cyanate, 100 g

sc-236899A
100 g
$34.00