SN-38 Carboxylate Disodium Salt (CAS 142677-15-4)

SN-38 Carboxylate Disodium Salt, a water-soluble derivative of SN-38, plays a role in research focused on understanding the intricacies of cellular mechanisms at the molecular level. SN-38 itself is an active metabolite of irinotecan, known for its potent inhibition of topoisomerase I, an enzyme critical for DNA replication and transcription processes in cells. By stabilizing the transient complex between the topoisomerase I enzyme and DNA, SN-38 induces DNA damage, leading to cell cycle arrest and apoptosis in rapidly dividing cells. This action highlights its utility in studies aimed at dissecting the pathways involved in cell proliferation and death, providing insights into the cellular responses to DNA damage. The solubility of SN-38 Carboxylate Disodium Salt in aqueous solutions facilitates its use in various in vitro research models, allowing for a more detailed exploration of its biochemical properties and interactions at the cellular level. This derivative′s enhanced solubility and bioavailability make it particularly valuable for studies requiring precise control over dosage and concentration, enabling researchers to elucidate the molecular mechanisms underlying its activity and to explore its potential applications in the field of cancer research and beyond.