sMtCK Antibody (B-4): sc-376040

sMtCK Antibody (B-4) is a mouse monoclonal IgM antibody that detects sMtCK protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-sMtCK antibody (B-4) is available as the non-conjugated form. sMtCK, a member of the creatine kinase family, plays a crucial role in cellular energy metabolism by catalyzing the reversible transfer of phosphate from phosphocreatine to adenosine diphosphate (ADP), thereby regenerating adenosine triphosphate (ATP) in tissues with high and fluctuating energy demands. This function is particularly important in muscle cells, neurons, and other tissues that require rapid ATP replenishment to maintain cellular activities and homeostasis. sMtCK is predominantly located in the mitochondria, where sMtCK is essential for maintaining energy supply during periods of increased metabolic activity. Mitochondrial localization of sMtCK ensures ATP production in close proximity to energy consumption sites, enhancing the efficiency of energy transfer and utilization within cells. By providing localized ATP, sMtCK supports critical processes such as muscle contraction, neurotransmission, and cellular signaling, making sMtCK a key player in overall cellular function and health.

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sMtCK Antibody (B-4) References:

1. Complete nucleotide sequence of the human creatine kinase B gene.  |  Mariman, EC., et al. 1989. Nucleic Acids Res. 17: 6385. PMID: 2771648
2. Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase.  |  Haas, RC., et al. 1989. J Biol Chem. 264: 2890-7. PMID: 2914937
3. cDNA cloning and mapping of the human creatine kinase M gene to 19q13.  |  Nigro, JM., et al. 1987. Am J Hum Genet. 40: 115-25. PMID: 3031982
4. Structure and expression of the human creatine kinase B gene.  |  Mariman, EC., et al. 1987. Genomics. 1: 126-37. PMID: 3692484
5. Creatine kinase in non-muscle tissues and cells.  |  Wallimann, T. and Hemmer, W. 1994. Mol Cell Biochem. 133-134: 193-220. PMID: 7808454
6. Some new aspects of creatine kinase (CK): compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiology.  |  Wallimann, T., et al. 1998. Biofactors. 8: 229-34. PMID: 9914824

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-sMtCK Antibody (B-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-sMtCK Antibody (B-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

sMtCK Antibody (B-4) Specifications

Alternate Product Name: sMtCK

Product Clone Name: B-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 59-93

Epitope Target: sMtCK

Epitope Species: rat

Product Reactivity/Detection: sMtCK

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for sMtCK Antibody (B-4): P: Blocking Peptide