SLC4A1AP Antibody (49): sc-136069
- SLC4A1AP Antibody (49) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 60-171 of SLC4A1AP of mouse origin
- recommended for detection of SLC4A1AP of mouse, rat and human origin by WB, IP and IF
- m-IgGκ BP-HRP is the preferred secondary detection reagent for SLC4A1AP Antibody (49) for WB applications. This reagent is now offered in a bundle with SLC4A1AP Antibody (49) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SLC4A1AP Antibody (49) is a mouse monoclonal IgG1 kappa light chain antibody that detects SLC4A1AP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-SLC4A1AP antibody (49) is available as a non-conjugated format. The solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP), also known as Kanadaptin or human lung cancer oncogene 3 protein (HLC-3), is a 796 amino acid multidomain protein widely expressed across various tissues, including kidney, lung, liver, brain, and both skeletal and cardiac muscle. SLC4A1AP is primarily localized in the nucleus, where SLC4A1AP plays a crucial role in cellular signaling pathways, influencing processes such as gene expression and cell proliferation. While SLC4A1AP was previously thought to function as an adaptor protein or chaperone for targeting kAE1 protein to the plasma membrane, recent research indicates SLC4A1AP does not interact with kAE1, suggesting a more complex role in cellular dynamics. The gene encoding SLC4A1AP is located on chromosome 2, which spans 237 million bases and constitutes approximately 8% of the human genome, with several genetic diseases associated with genes on this chromosome, including Harlequin ichthyosis, sitosterolemia, and Alström syndrome.
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SLC4A1AP Antibody (49) References:
- Signal- and importin-dependent nuclear targeting of the kidney anion exchanger 1-binding protein kanadaptin. | Hübner, S., et al. 2002. Biochem J. 361: 287-96. PMID: 11772400
- Mitochondrial and nuclear localization of kanadaptin. | Hübner, S., et al. 2003. Eur J Cell Biol. 82: 240-52. PMID: 12800979
- Human kanadaptin and kidney anion exchanger 1 (kAE1) do not interact in transfected HEK 293 cells. | Kittanakom, S., et al. 2004. Mol Membr Biol. 21: 395-402. PMID: 15764369
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. | Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
- ABCA12 is the major harlequin ichthyosis gene. | Thomas, AC., et al. 2006. J Invest Dermatol. 126: 2408-13. PMID: 16902423
- Spectrum of ALMS1 variants and evaluation of genotype-phenotype correlations in Alström syndrome. | Marshall, JD., et al. 2007. Hum Mutat. 28: 1114-23. PMID: 17594715
- Alström syndrome. | Marshall, JD., et al. 2007. Eur J Hum Genet. 15: 1193-202. PMID: 17940554
- Kanadaptin is a protein that interacts with the kidney but not the erythroid form of band 3. | Chen, J., et al. 1998. J Biol Chem. 273: 1038-43. PMID: 9422766
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SLC4A1AP Antibody (49) | sc-136069 | 200 µg/ml | $322.00 | |||
SLC4A1AP Antibody (49): m-IgGκ BP-HRP Bundle | sc-521325 | 200 µg Ab, 40 µg BP | $361.00 |