Molecular structure of SKF 83822 hydrobromide, CAS Number: 74115-08-5
SKF 83822 hydrobromide (CAS 74115-10-9)
Alternate Names:
6-Chloro-2,3,4,5-tetrahydro-1-(3-me thylphenyl)-3-(2-propenyl)-1H-3-benzazepine-7,8-di ol hydrobromide
Application:
SKF 83822 hydrobromide is a dopamine D1-like receptor agonist
CAS Number:
74115-10-9
Molecular Weight:
424.76
Molecular Formula:
C20H22ClNO2•HBr
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
SKF 83822 hydrobromide is structurally related to the endogenous neuropeptide somatostatin. It is a high affinity, selective dopamine D1-like receptor agonist (Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, alpha1A and alpha1B receptors respectively). It stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. SKF 83822 hydrobromide has been found to modulate a variety of processes, including neurotransmission, synaptic plasticity, gene expression, as well as cell proliferation, differentiation, and migration. By binding to the somatostatin receptor subtypes SSTR1 and SSTR2, This compound can modulate the activity of a variety of signal transduction pathways, including those involving adenylyl cyclase, phospholipase C, and protein kinase C.
SKF 83822 hydrobromide (CAS 74115-10-9) References
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- Differential involvement of cyclase- versus non-cyclase-coupled D1-like dopamine receptors in orofacial movement topography in mice: studies with SKF 83822. | Makihara, Y., et al. 2007. Neurosci Lett. 415: 6-10. PMID: 17234342
- Rotation and immediate-early gene expression in rats treated with the atypical D1 dopamine agonist SKF 83822. | Wirtshafter, D. 2007. Pharmacol Biochem Behav. 86: 505-10. PMID: 17306871
- Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling. | O'Sullivan, GJ., et al. 2008. Neuropharmacology. 54: 1051-61. PMID: 18367215
- Dopamine D(1) receptor activation of adenylyl cyclase, not phospholipase C, in the nucleus accumbens promotes maternal behavior onset in rats. | Stolzenberg, DS., et al. 2010. Horm Behav. 57: 96-104. PMID: 19799904
- Assessment of jaw movements by magnetic sensor in relation to topographies of orofacial behaviour in freely moving rats: Studies with the dopamine D(1)-like receptor agonists SKF 83822 vs SKF 83959. | Fujita, S., et al. 2010. Eur J Pharmacol. 632: 39-44. PMID: 20122923
- Dopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual functional regulation by G protein-coupled receptor kinase 2. | Verma, V., et al. 2010. J Biol Chem. 285: 35092-103. PMID: 20807772
- Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease. | Martella, G., et al. 2011. Neuroscience. 177: 240-51. PMID: 21195752
- Nr4a1-eGFP is a marker of striosome-matrix architecture, development and activity in the extended striatum. | Davis, MI. and Puhl, HL. 2011. PLoS One. 6: e16619. PMID: 21305052
- Subunit-specific modulation of [(3)H]MK-801 binding to NMDA receptors mediated by dopamine receptor ligands in rodent brain. | Wigestrand, MB., et al. 2012. Neurochem Int. 61: 266-76. PMID: 22561101
- Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells. | Ehrlich, AT., et al. 2013. Mol Pharmacol. 84: 476-86. PMID: 23842570
- Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors. | Abraham, AD., et al. 2016. Neuropsychopharmacology. 41: 2072-81. PMID: 26763483
- A new method allowing long-term potentiation recordings in hippocampal organotypic slices. | Paci, P., et al. 2017. Brain Behav. 7: e00692. PMID: 28523233
- PLPP/CIN inhibits dopamine D1 receptor-mediated seizure activity via DARPP-32 serine 97 dephosphorylation in the mouse hippocampus. | Kim, JE., et al. 2023. Neuropharmacology. 228: 109462. PMID: 36792029
Activator of:
D1DR, and D5DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SKF 83822 hydrobromide, 5 mg | sc-204284 | 5 mg | $198.00 | |||
| US: Only available in the US | ||||||
SKF 83822 hydrobromide, 50 mg | sc-204284A | 50 mg | $811.00 | |||
| US: Only available in the US | ||||||