SIRT2 Inhibitor, Inactive Control CAS: 304896-21-7
MF: C23H13Cl2N3O2
MW: 434.3
A SIRT3 inhibitor.

SIRT2 Inhibitor, Inactive Control (CAS 304896-21-7)

SIRT2 Inhibitor, Inactive Control | CAS 304896-21-7 is rated 5.0 out of 5 by 1.
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Alternate Names: AGK7
Application: SIRT2 Inhibitor, Inactive Control is a SIRT3 inhibitor
CAS Number: 304896-21-7
Purity: ≥97%
Molecular Weight: 434.3
Molecular Formula: C23H13Cl2N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

SIRT2 Inhibitor, Inactive Control, AGK7 is a cell-permeable structural isomer of SIRT2(sirtuin 2) Inhibitor, AGK2 (sc-202813) that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1 and SIRT2, respectively). SIRT2 Inhibitor, Inactive Control, AGK7 poorly affects both α-synuclein-mediated toxicity and α-Syn aggregation in α-Syn-H4 cells. SIRT2 Inhibitor, Inactive Control, AGK7 is an inhibitor of SIRT1(sirtuin 1) and SIRT3(sirtuin 3).


References

1. Outeiro, T.F. et al. 2007. Science. 317(5837): 516-519. PMID: 17588900

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at 4° C
Refractive Index :
n20D 1.72
IC50 :
SIRT3: IC50 = >5 µM; SIRT1: IC50 = >50 µM; SIRT2: IC50 = >50 µM
pK Values :
pKa: 9.17 (Predicted), pKb: 2.13 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1372572
SMILES :
C1=CC2=C(C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)/C#N)N=CC=C2

Download SDS (MSDS)

Certificate of Analysis

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SIRT2 Inhibitor, Inactive Control (CAS 304896-21-7)  Product Citations

See how others have used SIRT2 Inhibitor, Inactive Control (CAS 304896-21-7). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 29512306  J Cachexia Sarcopenia Muscle. 585-602.

Citations 1 to 1 of 1 total

What is the recommended dosage of this product for use in human cells in vitro?

Asked by: ChemSynth123
Thank you for your question. SIRT2 Inhibitor, Inactive Control, AGK7 (CAS 304896-21-7): sc-204281 was used in a concentration of 10µM in the paper listed under References on the Description tab. Please note, AGK7 was used on human H4 cells while testing α-Syn-mediated toxicity.
Answered by: Chemical Support 7
Date published: 2017-03-02
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Rated 5 out of 5 by from Outeiro Outeiro, TF. et al. (PubMed 17588900) reported that inhibition of SIRT2 via AGK7 rescued alpha-synuclein-mediated toxicity in models of Parkinson's disease. Furthermore, the inhibitor protected against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. -SCBT Publication Review
Date published: 2015-05-25
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