Molecular structure of SIB 1893, CAS Number: 6266-99-5
SIB 1893 (CAS 6266-99-5)
Alternate Names:
2-methyl-6-(2-phenylethenyl)pyridine; [E]-2-Methyl-6-[2-phenylethenyl]pyridine
Application:
SIB 1893 is a selective antagonist of mGluR-5
CAS Number:
6266-99-5
Molecular Weight:
195.26
Molecular Formula:
C14H13N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
SIB 1893 is a highly selective non-competitive antagonist for the mGluR-5 (metabotropic glutamate receptor 5 type); displays an IC50 value of 0.3 μM at hmGluR-5, compared with > 100 μM at hmGluR-1b, hmGluR-2, hmGluR-6, hmGluR-7 and hmGluR-8.
SIB 1893 (CAS 6266-99-5) References
Varney et al (1999) SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J.Pharmacol.Exp.Ther. 290 170. Chapman et al (2000) Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). Neuropharmacology 39 1567. Mathiesen et al (2003) Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br.J.Pharmacol. 138 1026.Inhibitor of:
mGluR-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SIB 1893, 10 mg | sc-203262 | 10 mg | $141.00 | |||
| US: Only available in the US | ||||||
SIB 1893, 50 mg | sc-203262A | 50 mg | $599.00 | |||
| US: Only available in the US | ||||||