Sclerotiorin (CAS 549-23-5)
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Sclerotiorin is a polyketide pigment predominantly researched for its antifungal and antioxidative properties. In agricultural research, sclerotiorin is studied for its potential to inhibit the growth of various plant pathogenic fungi, offering insights into environmentally sustainable crop protection strategies. Moreover, its role in oxidative stress pathways is a subject of investigation, particularly in understanding the mechanisms of reactive oxygen species (ROS) scavenging. Researchers are delving into how sclerotiorin interacts with cellular components, which could illuminate its broader role in biological systems and contribute to the development of novel industrial applications, such as its incorporation into bio-based materials for enhanced durability and resistance to degradation. Additionally, the chemical′s unique structural coloration properties are of interest in the field of material sciences, where it is explored for use in creating organic dyes and pigments.
Sclerotiorin (CAS 549-23-5) References
- Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones. | Tomoda, H., et al. 1999. J Antibiot (Tokyo). 52: 160-70. PMID: 10344570
- Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase. | Chidananda, C., et al. 2006. Biotechnol Lett. 28: 1633-6. PMID: 16900332
- Quorum sensing as a method for improving sclerotiorin production in Penicillium sclerotiorum. | Raina, S., et al. 2010. J Biotechnol. 148: 91-8. PMID: 20438771
- Reengineering an azaphilone biosynthesis pathway in Aspergillus nidulans to create lipoxygenase inhibitors. | Somoza, AD., et al. 2012. Org Lett. 14: 972-5. PMID: 22296232
- Synthesis and antifungal activity of novel sclerotiorin analogues. | Lin, L., et al. 2012. J Agric Food Chem. 60: 4480-91. PMID: 22439963
- Anticancer activity of sclerotiorin, isolated from an endophytic fungus Cephalotheca faveolata Yaguchi, Nishim. & Udagawa. | Giridharan, P., et al. 2012. Indian J Exp Biol. 50: 464-8. PMID: 22822525
- Design, synthesis and fungicidal activity of novel sclerotiorin derivatives. | Lin, L., et al. 2012. Chem Biol Drug Des. 80: 682-92. PMID: 22834771
- Bioactive metabolites from Chaetomium aureum: structure elucidation and inhibition of the Hsp90 machine chaperoning activity. | Kabbaj, FZ., et al. 2015. Bioorg Med Chem. 23: 126-31. PMID: 25482429
- Sclerotiorin is non-mutagenic and inhibits human PMNL 5-lipoxygenase and platelet aggregation. | Chidananda, C., et al. 2015. Indian J Exp Biol. 53: 228-31. PMID: 26011984
- Sclerotiorin inhibits protein kinase G from Mycobacterium tuberculosis and impairs mycobacterial growth in macrophages. | Chen, D., et al. 2017. Tuberculosis (Edinb). 103: 37-43. PMID: 28237032
- Solid-liquid Interface Screening SystemーApplication to the Screening of Antibiotic and Cytotoxic Substance-producing Fungi. | Oda, S., et al. 2019. Biocontrol Sci. 24: 47-56. PMID: 30880313
- Preparation, COX-2 Inhibition and Anticancer Activity of Sclerotiorin Derivatives. | Chen, T., et al. 2020. Mar Drugs. 19: PMID: 33383842
- Anti-Inflammatory Azaphilones from the Edible Alga-Derived Fungus Penicillium sclerotiorum. | Wang, HC., et al. 2021. Mar Drugs. 19: PMID: 34677428
- Investigating the disease-modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition. | Ayyolath, A., et al. 2023. Chem Biol Drug Des.. PMID: 37076430
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sclerotiorin, 500 µg | sc-205505 | 500 µg | $84.00 | |||
Sclerotiorin, 1 mg | sc-205505A | 1 mg | $203.00 |