SB220025 CAS: 165806-53-1
MF: C18H19FN6
MW: 338.4
A specific and potent human p38 mitogen-activated protein kinase.

SB220025 (CAS 165806-53-1)

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Synonym: 5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole
Application: A specific and potent human p38 mitogen-activated protein kinase
CAS Number: 165806-53-1
Purity: ≥95%
Molecular Weight: 338.4
Molecular Formula: C18H19FN6
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* Refer to Certificate of Analysis for lot specific data (including water content).
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SB220025 is a specific and potent human p38 mitogen-activated protein kinase. It has been shown to reduce the production of tumor necrosis factor induced by lipopolysaccharide. SB220025 has been found to reduce the expression of interleukin-1β and tumor necrosis factor-α and inhibit angiogenesis over the course of granuloma development. SB220025 has also been found to be capable of reducing inflammatory cytokine production, and thus could be a potential effective treatment for chronic proliferative inflammatory disease.


References

1. Jackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284: 687-692. PMID: 9454815
2. Wang, Z., et al. 1998. Structure. 6: 1117-1128. PMID: 9753691

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml).
Storage :
Store at -20° C
Melting Point :
242.54° C (Predicted)
Boiling Point :
611.86° C at 760 mmHg (Predicted)
Density :
1.42 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
p38α: IC50 = 60 nM (human); ERK 2: IC50 = 19 µM (human)
Ki Data :
Casein kinase I δ: Ki= 12.59 nM (human); Casein kinase I α: Ki= 12.59 nM (human); Tyrosine-protein kinase LCK: Ki= 125.89 nM (human); PKC ν: Ki= 251.19 nM (human); Lyn: Ki= 316.23 nM (human)
pK Values :
pKb: 9.92 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5164
MDL Number :
MFCD02179213
SMILES :
C1CNCCC1N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F

Download SDS (MSDS)

Certificate of Analysis

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