Molecular structure of (S)-SLV 319, CAS Number: 464213-10-3
(S)-SLV 319 (CAS 464213-10-3)
Alternate Names:
JD 5001; BMS 646256; Ibipinabant
Application:
(S)-SLV 319 is a potent, selective CB1 receptor antagonist
CAS Number:
464213-10-3
Purity:
≥98%
Molecular Weight:
487.40
Molecular Formula:
C23H20Cl2N4O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Central cannabinoid receptor antagonists may have potential in the treatment of a number of diseases such as neuro-inflammatory disorders, cognitive disorders, septic shock, obesity, psychosis, addiction, and gastrointestinal disorders.1 (S)-SLV 319 is a strong and selective CB1 receptor antagonist with Ki values of 7.8 and 7,943 nM for CB1 and CB2, respectively.1 (S)-SLV 319 is less lipophilic and therefore more water soluble than other known CB1 receptor ligands.2
(S)-SLV 319 (CAS 464213-10-3) References
- Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. | Lange, JH., et al. 2004. J Med Chem. 47: 627-43. PMID: 14736243
- Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity. | Lange, JH., et al. 2005. Bioorg Med Chem Lett. 15: 4794-8. PMID: 16140010
- Constitutive activity at the cannabinoid CB(1) receptor and behavioral responses. | Hanlon, KE. and Vanderah, TW. 2010. Methods Enzymol. 484: 3-30. PMID: 21036224
- Mitochondrial ADP/ATP exchange inhibition: a novel off-target mechanism underlying ibipinabant-induced myotoxicity. | Schirris, TJ., et al. 2015. Sci Rep. 5: 14533. PMID: 26416158
- Characterization of drug-induced human mitochondrial ADP/ATP carrier inhibition. | Jaiquel Baron, S., et al. 2021. Theranostics. 11: 5077-5091. PMID: 33859735
Inhibitor of:
CB1, and CB2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-SLV 319, 1 mg | sc-222285 | 1 mg | $92.00 | |||
(S)-SLV 319, 5 mg | sc-222285A | 5 mg | $311.00 |