Molecular structure of S(−)-UH-301 hydrochloride, CAS Number: 127126-22-1
S(−)-UH-301 hydrochloride (CAS 127126-22-1)
Alternate Names:
S(−)-5-Fluoro-8-hydroxy-2-dipropylamino-1,2,3,4-tetrahydronaphthalene hydrochloride
Application:
S(−)-UH-301 hydrochloride is a potent and selective 5-HT1A serotonin receptor antagonist
CAS Number:
127126-22-1
Purity:
≥98%
Molecular Weight:
301.83
Molecular Formula:
C16H24FNO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
S(−)-UH-301 hydrochloride is a compound that functions as a selective and potent antagonist of the serotonin 5-HT4 receptor. It acts by binding to the 5-HT4 receptor and inhibiting its activation by serotonin, thereby blocking the downstream signaling pathways associated with this receptor. S(−)-Uh-301 Hydrochloride′s mechanism of action involves interfering with the binding of serotonin to the 5-HT4 receptor, thereby preventing the receptor from initiating its normal cellular response. By targeting the 5-HT4 receptor, S(−)-UH-301 hydrochloride can modulate the activity of this receptor in experimental applications.
S(−)-UH-301 hydrochloride (CAS 127126-22-1) References
- Nasal absorption of (S)-UH-301 and its transport into the cerebrospinal fluid of rats. | Dahlin, M. and Björk, E. 2000. Int J Pharm. 195: 197-205. PMID: 10675697
- An integrative pharmacokinetic and pharmacodynamic study of the 5-HT1A receptor antagonist (S)-UH-301 in the rat. | Yan, H., et al. 2002. Eur Neuropsychopharmacol. 12: 101-10. PMID: 11872325
- The novel 5-HT1A receptor antagonist (S)-UH-301 prevents (R)-8-OH-DPAT-induced decrease in interstitial concentrations of serotonin in the rat hippocampus. | Nomikos, GG., et al. 1992. Eur J Pharmacol. 216: 373-8. PMID: 1425929
- Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects. | Björk, L., et al. 1991. J Pharmacol Exp Ther. 258: 58-65. PMID: 1830099
- Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate. | Matthews, H., et al. 2013. Malar J. 12: 359. PMID: 24107123
- Serotonergic modulation of slow inward rectification in mesencephalic trigeminal neurons. | Tanaka, S., et al. 2019. Brain Res. 1718: 126-136. PMID: 31085157
- The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model. | Wertman, JN., et al. 2020. Elife. 9: PMID: 32720645
- Production of serotonin syndrome by 8-OH DPAT in Cryptotis parva. | Darmani, NA. and Zhao, W. 1998. Physiol Behav. 65: 327-31. PMID: 9855483
Inhibitor of:
SR-1A.Activator of:
D2DR, and D3DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S(−)-UH-301 hydrochloride, 1 mg | sc-253462 | 1 mg | $135.00 | |||
S(−)-UH-301 hydrochloride, 5 mg | sc-253462A | 5 mg | $800.00 |