S(−)-UH-301 hydrochloride CAS: 127126-22-1
MF: C16H24FNO•HCl
MW: 301.83
A potent and selective 5-HT1A serotonin receptor antagonist.

S(−)-UH-301 hydrochloride (CAS 127126-22-1)

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Alternate Names: S(−)-5-Fluoro-8-hydroxy-2-dipropylamino-1,2,3,4-tetrahydronaphthalene hydrochloride
Application: S(−)-UH-301 hydrochloride is a potent and selective 5-HT1A serotonin receptor antagonist
CAS Number: 127126-22-1
Purity: ≥98%
Molecular Weight: 301.83
Molecular Formula: C16H24FNO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

S(−)-UH-301 hydrochloride is a potent, selective 5-HT1A serotonin receptor antagonist and D2/D3 dopamine receptor agonist.


References

Björk, L., et al., Pharmacology of the novel 5-hydroxytryptamine 1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: Inhibitor of (R)-8-Hydroxy-2-(dipropylamino)tetralin-induced effects. J. Pharmacol. Exp. Ther. 258, 58, (1991) Björk, L., et al., (S)-UH-301 antagonizes (R)-8-OH-DPAT-induced cardiovascular effects in the rat. Eur. J. Pharmacol. 199, 367, (1991) Ahlenius, S., et al., In vivo intrinsic efficacy of the 5-HT1A receptor antagonists NAD-299, WAY-100,635 and (S)-(−)-UH-301 at rat brain monoamine receptors. Eur. Neuropsychopharmacol. 9, 15-19, (1999) Hillver, S.E., et al., Synthesis and pharmacology of the enantiomers of UH301: opposing interactions with 5-HT1A receptors. Chirality 8, 531-544, (1996) Arborelius, L, et al., The 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons. Naunyn Schmiedebergs Arch. Pharmacol. 347, 353-362, (1993)

Physical State :
Solid
Solubility :
H2O: >20 mg/mL: ethanol: soluble
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
10236521
MDL Number :
MFCD00210226
SMILES :
CCCN(CCC)[[email protected]]1CCC2=C(C=CC(=C2C1)O)F.Cl

Download SDS (MSDS)

Certificate of Analysis

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