Molecular structure of S-Methylisothiourea sulfate, CAS Number: 867-44-7
S-Methylisothiourea sulfate (CAS 867-44-7)
See product citations (8)
Alternate Names:
2-Methyl-2-thiopseudourea hemisulfate salt; S-Methyl-ITU, S-Methylthiuronium sulfate; SMT
Application:
S-Methylisothiourea sulfate is a potent and selective iNOS and NOS2 inhibitor
CAS Number:
867-44-7
Molecular Weight:
278.36
Molecular Formula:
C4H12N4S2•H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
S-Methylisothiourea Sulfate (SMT) is a potent and selective inhibitor of NOS2 (iNOS). SMT has been shown to be a greater inhibitor of NOS2 in immunostimulated cultured macrophages and vascular muscle cells than other NOS inhibitors, including NG-methyl-L-arginine (MeArg). In the presence of SMT, there was a significant decrease in infarct volume, neuro-behavioral abnormality, brain edema, number of apoptotic cells in penumbra and NOx levels in plasma and brain of rats with transient focal cerebral ischemia.
S-Methylisothiourea sulfate (CAS 867-44-7) References
- S-Methylisothiourea sulfate improves renal, but not hepatic dysfunction in canine endotoxic shock model. | Mitaka, C., et al. 2000. Intensive Care Med. 26: 117-24. PMID: 10663292
- Improvement of intestinal motility using S-methylisothiourea in postoperative ileus. | Uenoyama, S., et al. 2004. Am J Surg. 187: 93-7. PMID: 14706594
- Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats. | Guzel, A., et al. 2008. Int J Pediatr Otorhinolaryngol. 72: 1241-50. PMID: 18573544
- Neuroprotective effect of s-methylisothiourea in transient focal cerebral ischemia in rat. | ArunaDevi, R., et al. 2010. Nitric Oxide. 22: 1-10. PMID: 19836458
- Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway. | Wang, KL., et al. 2016. Biofouling. 32: 35-44. PMID: 26732984
- Cesium carbonate-promoted synthesis of aryl methyl sulfides using S-methylisothiourea sulfate under transition-metal-free conditions. | Zhang, C., et al. 2018. Org Biomol Chem. 16: 6316-6321. PMID: 30128466
- Poly I:C and R848 facilitate nitric oxide production via inducible nitric oxide synthase in chicks. | Tachibana, T., et al. 2022. Comp Biochem Physiol A Mol Integr Physiol. 269: 111211. PMID: 35417747
- Canagliflozin Attenuates Lipotoxicity in Cardiomyocytes by Inhibiting Inflammation and Ferroptosis through Activating AMPK Pathway. | Zhang, W., et al. 2023. Int J Mol Sci. 24: PMID: 36614295
- Echinacea Polyphenols Inhibit NLRP3-Dependent Pyroptosis, Apoptosis, and Necroptosis via Suppressing NO Production during Lipopolysaccharide-Induced Acute Lung Injury. | Guo, J., et al. 2023. J Agric Food Chem. 71: 7289-7298. PMID: 37154470
- Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. | Szabó, C., et al. 1994. Proc Natl Acad Sci U S A. 91: 12472-6. PMID: 7528923
Inhibitor of:
AtNOS1, GCS-β-1, NOS1, NOS2, NOS3, sGC α1, sGC α2I, and sGC β2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-Methylisothiourea sulfate, 1 g | sc-3566 | 1 g | $20.00 | |||
S-Methylisothiourea sulfate, 100 g | sc-3566A | 100 g | $23.00 |