Date published: 2026-2-18

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(S)-(−)-α-Methylbenzyl isocyanide (CAS 21872-32-2)

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CAS Number:
21872-32-2
Purity:
96%
Molecular Weight:
131.17
Molecular Formula:
C9H9N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(S)-(−)-alpha-Methylbenzyl isocyanide has various applications in scientific research. Particularly, it holds significant importance in the domain of organic chemistry. This compound serves as a ligand in the creation of diverse metal complexes. Additionally, it serves as a building block in the synthesis of a wide range of organic compounds. It is also used as a catalyst in the synthesis of various organic compounds.


(S)-(−)-α-Methylbenzyl isocyanide (CAS 21872-32-2) References

  1. Stereoselective metabolism of nicotine and tobacco-specific N-nitrosamines to 4-hydroxy-4-(3-pyridyl)butanoic acid in rats.  |  Trushin, N. and Hecht, SS. 1999. Chem Res Toxicol. 12: 164-71. PMID: 10027794
  2. Determination of the optical purity of (R)-terbutaline by 1H-NMR and RP-LC using chiral derivatizing agent, (S)-(-)-alpha-methylbenzyl isocyanate.  |  Kim, KH., et al. 2001. J Pharm Biomed Anal. 25: 947-56. PMID: 11377078
  3. Stereoselective chromatography of cardiovascular drugs: an update.  |  Bojarski, J. 2002. J Biochem Biophys Methods. 54: 197-220. PMID: 12543499
  4. Multipoint molecular recognition of amino acids and biogenic amines by ureidocalix[5]arene receptors.  |  Ballistreri, FP., et al. 2003. Org Lett. 5: 1071-4. PMID: 12659576
  5. Resolution of salbutamol enantiomers in human urine by reversed-phase high performance liquid chromatography after derivatization with (S)-(-)-alpha-methylbenzyl isocyanate.  |  Kim, KH., et al. 1997. Arch Pharm Res. 20: 486-90. PMID: 18982495
  6. Zinc chloride promoted formal oxidative coupling of aromatic aldehydes and isocyanides to alpha-ketoamides.  |  Bouma, M., et al. 2010. J Org Chem. 75: 2748-51. PMID: 20302346
  7. A review of use of enantiomers in homeopathy.  |  Kuzeff, RM. 2012. ISRN Toxicol. 2012: 575292. PMID: 23724294
  8. Single-Site Cobalt Catalysts at New Zr12(μ3-O)8(μ3-OH)8(μ2-OH)6 Metal-Organic Framework Nodes for Highly Active Hydrogenation of Nitroarenes, Nitriles, and Isocyanides.  |  Ji, P., et al. 2017. J Am Chem Soc. 139: 7004-7011. PMID: 28478673
  9. A self-assembled nanohelix for white circularly polarized luminescence via chirality and energy transfer.  |  Ma, S., et al. 2020. Nanoscale. 12: 7895-7901. PMID: 32227012
  10. Isocyanate derivatization coupled with phospholipid removal microelution-solid phase extraction for the simultaneous quantification of (S)-metoprolol and (S)-α-hydroxymetoprolol in human plasma with LC-MS/MS.  |  Meloche, M., et al. 2021. J Pharm Biomed Anal. 204: 114263. PMID: 34274593
  11. General stereoretentive preparation of chiral secondary mixed alkylmagnesium reagents and their use for enantioselective electrophilic aminations.  |  Kremsmair, A., et al. 2021. Chem Sci. 13: 44-49. PMID: 35059149
  12. Discovery of Benzopyrrolizidines as Promising Antigiardiasic Agents.  |  Auriostigue-Bautista, JC., et al. 2021. Front Cell Infect Microbiol. 11: 828100. PMID: 35096662
  13. Synthesis of Alternating Polyisocyanate Copolymers by Anionic Polymerization for Mimicking Amphiphilic Helical Peptides.  |  Bak, IG., et al. 2022. Angew Chem Int Ed Engl. 61: e202212398. PMID: 36268639
  14. DEVELOPMENT AND VALIDATION OF A NEW HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR ENANTIOSEPARATION OF DORZOLAMIDE HYDROCHLORIDE ON A COATED CELLULOSE PHENYLCARBAMATE CHIRAL STATIONARY PHASE  |  Mojtaba Shamsipur, Assem Abdollahpour & Rouhollah Heydari. 2011. Journal of Liquid Chromatography & Related Technologies. 34: 1367-1380.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(S)-(−)-α-Methylbenzyl isocyanide, 1 g

sc-229198
1 g
$151.00