S-Adenosylhomocysteine-d4 (CAS 979-92-0 (unlabeled))
QUICK LINKS
S-Adenosylhomocysteine-d4 is a stable isotope-labeled analog of S-Adenosylhomocysteine (SAH), which is employed in biochemical and molecular biology research. It acts as a methyltransferase inhibitor and is used to study the role of methylation in epigenetic regulation and gene expression. The incorporation of deuterium atoms (d4) allows for precise tracing and quantification in mass spectrometry-based experiments, aiding in the investigation of methylation pathways. Researchers use S-Adenosylhomocysteine-d4 to explore the kinetics and dynamics of SAH-dependent reactions, such as transmethylation, and to elucidate the mechanisms by which SAH influences cellular metabolism. Additionally, this compound is instrumental in probing the relationship between methyltransferase activity and various biological processes, including DNA, RNA, and protein methylation. The deuterium labeling enhances the stability of the molecule, reducing the exchange with hydrogen, which is particularly beneficial for in vitro studies.
S-Adenosylhomocysteine-d4 (CAS 979-92-0 (unlabeled)) References
- LC-MS/MS identification of the one-carbon cycle metabolites in human plasma. | Gardner, LA., et al. 2013. Electrophoresis. 34: 1710-6. PMID: 23417555
- Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. | Zhu, J., et al. 2019. Cell Metab. 30: 865-876.e5. PMID: 31607565
- Robotic automation of a UHPLC/MS-MS method profiling one-carbon metabolites, amino acids, and precursors in plasma. | Andraos, S., et al. 2020. Anal Biochem. 592: 113558. PMID: 31911045
- Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress. | Schwörer, S., et al. 2020. EMBO J. 39: e103334. PMID: 32134147
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice. | Fling, RR., et al. 2020. Sci Rep. 10: 14831. PMID: 32908189
- Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry. | Pearson, LA., et al. 2021. SLAS Discov. 26: 749-756. PMID: 33724070
- Chromium induced neurotoxicity by altering metabolism in zebrafish larvae. | Xu, Y., et al. 2021. Ecotoxicol Environ Saf. 228: 112983. PMID: 34781135
- Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication. | Bardiot, D., et al. 2022. Molecules. 27: PMID: 35164317
- PAH-induced metabolic changes related to inflammation in childhood asthma. | Wu, H., et al. 2023. Environ Sci Pollut Res Int. 30: 13739-13754. PMID: 36136199
- One-carbon metabolite supplementation to heifers for the first 14 d of the estrous cycle alters the plasma and hepatic one-carbon metabolite pool and methionine-folate cycle enzyme transcript abundance in a dose-dependent manner. | Crouse, MS., et al. 2023. J Anim Sci. 101: PMID: 36566452
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-Adenosylhomocysteine-d4, 500 µg | sc-296290 | 500 µg | $198.00 | |||
S-Adenosylhomocysteine-d4, 1 mg | sc-296290A | 1 mg | $352.00 |