Molecular structure of S-3448, CAS Number: 254877-04-8
S-3448 (CAS 254877-04-8)
Alternate Names:
2-[[(4-Chlorophenyl)sulfonyl]amino]-4,5-dimethoxy-N-[4-(4-thiomorpholinylsulfonyl)phenyl]benzamide
Application:
S-3448 is An anthranilic acid derivative shown to activate guanylyl cyclase
CAS Number:
254877-04-8
Molecular Weight:
612.14
Molecular Formula:
C25H26ClN3O7S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A new class of sGC agonists. A
S-3448 (CAS 254877-04-8) References
- Pharmacologic modulators of soluble guanylate cyclase/cyclic guanosine monophosphate in the vascular system - from bench top to bedside. | Jackson, EB., et al. 2007. Curr Vasc Pharmacol. 5: 1-14. PMID: 17266609
- Probing the presence of the ligand-binding haem in cellular nitric oxide receptors. | Roy, B., et al. 2008. Br J Pharmacol. 153: 1495-504. PMID: 18204474
- Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress. | Zhou, Z., et al. 2008. Am J Physiol Heart Circ Physiol. 295: H1763-71. PMID: 18757489
- Exploring the potential of NO-independent stimulators and activators of soluble guanylate cyclase for the medical treatment of erectile dysfunction. | Gur, S., et al. 2010. Curr Pharm Des. 16: 1619-33. PMID: 20201788
- The chemistry and biology of soluble guanylate cyclase stimulators and activators. | Follmann, M., et al. 2013. Angew Chem Int Ed Engl. 52: 9442-62. PMID: 23963798
- The Potential of sGC Modulators for the Treatment of Age-Related Fibrosis: A Mini-Review. | Sandner, P., et al. 2017. Gerontology. 63: 216-227. PMID: 27784018
- Current and Future Treatments for Persistent Pulmonary Hypertension in the Newborn. | Pedersen, J., et al. 2018. Basic Clin Pharmacol Toxicol. 123: 392-406. PMID: 29855164
- Soluble Guanylate Cyclase Stimulators and Activators. | Sandner, P., et al. 2021. Handb Exp Pharmacol. 264: 355-394. PMID: 30689085
- Soluble GC stimulators and activators: Past, present and future. | Sandner, P., et al. 2021. Br J Pharmacol.. PMID: 34600441
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GCS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-3448, 2.5 mg | sc-212811 | 2.5 mg | $390.00 |