RP2 Antibody (37.28): sc-81892

RP2 Antibody (37.28) is a mouse monoclonal IgG2b antibody that detects RP2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). RP2, also known as TBCCD2, is a 350 amino acid protein that plays a crucial role in retinal development by stimulating the GTPase activity of tubulin and acting as a guanine nucleotide dissociation inhibitor for ARL3 (ADP-ribosylation factor-like 3). This interaction is vital as it prevents the dissociation of the GTP-bound form of ARL3, thereby regulating cellular processes essential for maintaining photoreceptor cell function. RP2 is predominantly localized to the cytoplasmic side of the cell membrane and is expressed ubiquitously, highlighting its importance in various cellular contexts. RP2 features one C-CAP/cofactor C-like domain and undergoes post-translational modifications such as myristoylation and palmitoylation, which are critical for proper membrane targeting and function. Mutations in the gene encoding RP2 are linked to retinitis pigmentosa type 2 (RP2), a genetic disorder that leads to the degeneration of photoreceptor cells, resulting in night vision blindness and progressive loss of both peripheral and central vision. Anti-RP2 antibody (37.28) is an essential tool for researchers studying the molecular mechanisms underlying retinal diseases and the role of RP2 in cellular signaling pathways.

The preferred RP2 antibody is RP2 Antibody (C-9): sc-390220.