Date published: 2025-12-5

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Rp-8-Br-cGMPS (CAS 208445-06-1)

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Application:
Rp-8-Br-cGMPS is a cGMP analog which blocks cGMP dependent protein kinase
CAS Number:
208445-06-1
Purity:
98%
Molecular Weight:
462.15
Molecular Formula:
C10H10BrN5O6PS•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Rp-8-Br-cGMPS is a synthetic analogue of cyclic guanosine monophosphate (cGMP) and functions as a potent inhibitor of protein kinase G (PKG). This compound is used in various research applications to study the cellular signaling pathways mediated by cGMP-dependent protein kinase. By selectively blocking PKG activity, Rp-8-Br-cGMPS allows scientists to dissect the role of cGMP and PKG in processes such as vasodilation, platelet aggregation, and neuronal signaling. It is also valuable in exploring the mechanisms of learning and memory, as PKG is implicated in long-term potentiation within the hippocampus. Additionally, research involving Rp-8-Br-cGMPS contributes to the understanding of smooth muscle relaxation and cardiovascular function. The compound′s specificity in inhibiting PKG-related pathways is critical for elucidating the physiological and pathological roles of cGMP signaling.


Rp-8-Br-cGMPS (CAS 208445-06-1) References

  1. Effect of four cGMP analogues with different mechanisms of action on hormone release by porcine ovarian granulosa cells in vitro.  |  Sirotkin, AV., et al. 2000. Exp Clin Endocrinol Diabetes. 108: 214-9. PMID: 10926319
  2. Effect of cGMP analogues and protein kinase G blocker on secretory activity, apoptosis and the cAMP/protein kinase A system in porcine ovarian granulosa cells in vitro.  |  Sirotkin, AV., et al. 2000. J Steroid Biochem Mol Biol. 74: 1-9. PMID: 11074350
  3. The role of cyclic nucleotides and calcium in the relaxation produced by amrinone in rat aorta.  |  van der Zypp, A., et al. 2000. Gen Pharmacol. 34: 245-53. PMID: 11282218
  4. Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation.  |  Schmidtko, A., et al. 2003. Nitric Oxide. 8: 89-94. PMID: 12620371
  5. Modulation of synaptic function by cGMP and cGMP-gated cation channels.  |  Barnstable, CJ., et al. 2004. Neurochem Int. 45: 875-84. PMID: 15312982
  6. Modulation of cardiac ERG1 K(+) channels by cGMP signaling.  |  Mewe, M., et al. 2010. J Mol Cell Cardiol. 49: 48-57. PMID: 20188738
  7. Inhibitory Effects of Cytosolic Ca(2+) Concentration by Ginsenoside Ro Are Dependent on Phosphorylation of IP3RI and Dephosphorylation of ERK in Human Platelets.  |  Kwon, HW., et al. 2015. Evid Based Complement Alternat Med. 2015: 764906. PMID: 26355658
  8. Scutellarin Reduces Endothelium Dysfunction through the PKG-I Pathway.  |  Du, X., et al. 2015. Evid Based Complement Alternat Med. 2015: 430271. PMID: 26557858
  9. Nitric oxide impacts bovine sperm capacitation in a cGMP-dependent and cGMP-independent manner.  |  Maciel, VL., et al. 2019. Reprod Domest Anim. 54: 1612-1620. PMID: 31549441
  10. Scutellarin Reduces Cerebral Ischemia Reperfusion Injury Involving in Vascular Endothelium Protection and PKG Signal.  |  Chen, YJ., et al. 2021. Nat Prod Bioprospect. 11: 659-670. PMID: 34750765
  11. Rp-8-Br-guanosine-3',5'-cyclic monophosphorothioate inhibits relaxation elicited by nitroglycerin in rabbit aorta.  |  Nakazawa, M. and Imai, S. 1994. Eur J Pharmacol. 253: 179-81. PMID: 8013545
  12. Nitric oxide regulates luteinizing hormone-releasing hormone secretion.  |  Moretto, M., et al. 1993. Endocrinology. 133: 2399-402. PMID: 8104781
  13. Modulation of neutrophil migration by exogenous gaseous nitric oxide.  |  VanUffelen, BE., et al. 1996. J Leukoc Biol. 60: 94-100. PMID: 8699130
  14. Role of cyclic nucleotides in vasopressin-induced piglet pial artery dilation and opioid release.  |  Rossberg, MI. and Armstead, WM. 1997. Pediatr Res. 41: 498-504. PMID: 9098851
  15. Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP-mediated vasorelaxation.  |  Eckly-Michel, A., et al. 1997. Br J Pharmacol. 122: 158-64. PMID: 9298542

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Rp-8-Br-cGMPS, 500 µg

sc-200323
500 µg
$270.00