Molecular structure of Rosuvastatin-d6 Sodium Salt
Rosuvastatin-d6 Sodium Salt
Alternate Names:
7-[4-(4-Fluorophenyl)-6-(1-methylethyl-d6)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic Acid Sodium Salt
Application:
Rosuvastatin-d6 Sodium Salt is a labeled competitive HMGCR (HMG-CoA reductase) inhibitor
Molecular Weight:
509.56
Molecular Formula:
C22H21D6FN3NaO6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Rosuvastatin-d6 Sodium Salt is a compound that functions as a competitive inhibitor of HMG-CoA reductase, an enzyme involved in the biosynthesis of cholesterol. It acts by binding to the active site of the enzyme, preventing the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This inhibition leads to a decrease in intracellular cholesterol levels, which in turn upregulates the expression of LDL receptors on the cell surface. The increased number of LDL receptors enhances the uptake of circulating LDL cholesterol, thereby reducing the levels of LDL in the bloodstream. Rosuvastatin-d6 Sodium Salt has an impact on the expression of other genes involved in lipid metabolism, further contributing to its cholesterol-lowering effects. Rosuvastatin-d6 Sodium Salt exerts its action bytargeting the enzyme HMG-CoA reductase, disrupting the pathway of cholesterol.
Rosuvastatin-d6 Sodium Salt References
- A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). | Macwan, JS., et al. 2012. Anal Bioanal Chem. 402: 1217-27. PMID: 22108655
- Pharmacokinetic interaction between rosuvastatin and olmesartan: a randomized, open-label, 3-period, multiple-dose crossover study in healthy Korean male subjects. | Roh, H., et al. 2014. Clin Ther. 36: 1159-70. PMID: 25017182
- Pharmacokinetics of a telmisartan/rosuvastatin fixed-dose combination: a single-dose, randomized, open-label, 2-period crossover study in healthy Korean subjects. | Chae, DW., et al. 2015. Int J Clin Pharmacol Ther. 53: 883-9. PMID: 26329347
- Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake. | Morse, BL., et al. 2015. Drug Metab Dispos. 43: 1788-94. PMID: 26341276
- Simultaneous determination of rosuvastatin and amlodipine in human plasma using tandem mass spectrometry: Application to disposition kinetics. | Narapusetti, A., et al. 2015. J Adv Res. 6: 931-40. PMID: 26644931
- Investigation of the Bioequivalence of Rosuvastatin 20 mg Tablets after a Single Oral Administration in Mediterranean Arabs Using a Validated LC-MS/MS Method. | Zaid, AN., et al. 2016. Sci Pharm. 84: 536-546. PMID: 28117319
- Pharmacokinetics and bioequivalence of a rosuvastatin/ezetimibe fixed-dose combination tablet versus single agents in healthy male subjects . | Kang, WY., et al. 2018. Int J Clin Pharmacol Ther. 56: 43-52. PMID: 29162214
- Food Effect on Rosuvastatin Disposition and Low-Density Lipoprotein Cholesterol. | McLean, CC., et al. 2018. Clin Pharmacol Ther. 104: 525-533. PMID: 29218707
- Pharmacokinetic comparison of a fixed-dose combination versus concomitant administration of fimasartan, amlodipine, and rosuvastatin using partial replicated design in healthy adult subjects. | Oh, M., et al. 2018. Drug Des Devel Ther. 12: 1157-1164. PMID: 29780236
- Simultaneous quantitation of rosuvastatin and ezetimibe in human plasma by LC-MS/MS: Pharmacokinetic study of fixed-dose formulation and separate tablets. | Bhadoriya, A., et al. 2018. Biomed Chromatogr. 32: e4291. PMID: 29782035
- Comparison of the Pharmacokinetics of a Fixed-Dose Combination of Rosuvastatin/Metformin Sustained-Release (10/1000 mg) and Separate Tablets in Healthy Male Subjects. | Huh, KY., et al. 2021. Clin Pharmacol Drug Dev. 10: 207-213. PMID: 32579298
- The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality. | Kiander, W., et al. 2021. Pharm Res. 38: 1663-1675. PMID: 34647232
- A comprehensive pharmacogenomic study indicates roles for SLCO1B1, ABCG2 and SLCO2B1 in rosuvastatin pharmacokinetics. | Lehtisalo, M., et al. 2023. Br J Clin Pharmacol. 89: 242-252. PMID: 35942816
Inhibitor of:
HMGCR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rosuvastatin-d6 Sodium Salt, 1 mg | sc-219996 | 1 mg | $445.00 |