Molecular structure of RJR 2429 dihydrochloride, CAS Number: 1021418-53-0
RJR 2429 dihydrochloride (CAS 1021418-53-0)
Alternate Names:
(±)-2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane dihydrochloride
Application:
RJR 2429 dihydrochloride is a potent AChR agonist
CAS Number:
1021418-53-0
Molecular Weight:
261.19
Molecular Formula:
C12H16N2•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
RJR 2429 dihydrochloride is a potent AChR agonist that displays selectivity for alpha4beta2 (Ki = 1 nM) and alpha1betagammadelta subtypes (EC50 values are 297 and 55 nM, respectively). It induces dopamine release from striatal neurons (EC50 = 2 nM) and inhibits ion flux in thalamic neurons (IC50 = 154 nM). RJR 2429 dihydrochloride is also a putative alpha3beta4 agonist that potentiates catecholamine release.
RJR 2429 dihydrochloride (CAS 1021418-53-0) References
- UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes. | Sharples, CG., et al. 2000. J Neurosci. 20: 2783-91. PMID: 10751429
- Central nicotinic receptor ligands and pharmacophores. | Glennon, RA. and Dukat, M. 2000. Pharm Acta Helv. 74: 103-14. PMID: 10812946
- Agonists at the alpha4beta2 nicotinic acetylcholine receptors: structure-activity relationships and molecular modelling. | Tønder, JE. and Olesen, PH. 2001. Curr Med Chem. 8: 651-74. PMID: 11281847
- Competitive neuronal nicotinic receptor antagonists: a new direction for drug discovery. | Dwoskin, LP. and Crooks, PA. 2001. J Pharmacol Exp Ther. 298: 395-402. PMID: 11454899
- Characterization of functional nicotinic acetylcholine receptors involved in catecholamine release from the isolated rat adrenal gland. | Yokotani, K., et al. 2002. Eur J Pharmacol. 446: 83-7. PMID: 12098588
- Membrane potential fluorescence: a rapid and highly sensitive assay for nicotinic receptor channel function. | Fitch, RW., et al. 2003. Proc Natl Acad Sci U S A. 100: 4909-14. PMID: 12657731
- Design of ligands for the nicotinic acetylcholine receptors: the quest for selectivity. | Bunnelle, WH., et al. 2004. Curr Top Med Chem. 4: 299-334. PMID: 14754449
- Nicotinic agonists, antagonists, and modulators from natural sources. | Daly, JW. 2005. Cell Mol Neurobiol. 25: 513-52. PMID: 16075378
- Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line. | Roncarati, R., et al. 2008. Assay Drug Dev Technol. 6: 181-93. PMID: 18471073
- Pre-synaptic nicotinic receptors evoke endogenous glutamate and aspartate release from hippocampal synaptosomes by way of distinct coupling mechanisms. | Zappettini, S., et al. 2010. Br J Pharmacol. 161: 1161-71. PMID: 20633015
- Presynaptic nicotinic α7 and non-α7 receptors stimulate endogenous GABA release from rat hippocampal synaptosomes through two mechanisms of action. | Zappettini, S., et al. 2011. PLoS One. 6: e16911. PMID: 21346795
- Different presynaptic nicotinic receptor subtypes modulate in vivo and in vitro the release of glycine in the rat hippocampus. | Zappettini, S., et al. 2011. Neurochem Int. 59: 729-38. PMID: 21762741
- Nicotinic α7 receptor activation selectively potentiates the function of NMDA receptors in glutamatergic terminals of the nucleus accumbens. | Zappettini, S., et al. 2014. Front Cell Neurosci. 8: 332. PMID: 25360085
- Short- and Long-Term Effects of Cocaine on Enteric Neuronal Functions. | Elfers, K., et al. 2023. Cells. 12: PMID: 36831246
Activator of:
AChR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RJR 2429 dihydrochloride, 10 mg | sc-204237 | 10 mg | $192.00 | |||
RJR 2429 dihydrochloride, 50 mg | sc-204237A | 50 mg | $700.00 |