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Rifabutin (CAS 72559-06-9)

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Alternate Names:
Ansatipine; Ansamycin; Mycobutin
Application:
Rifabutin is a semisynthetic antibacterial derivative of Rifamycin S
CAS Number:
72559-06-9
Purity:
≥98%
Molecular Weight:
847.00
Molecular Formula:
C46H62N4O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Rifabutin is a compound of interest within the field of microbiology, where it is used in research studies to investigate its antibiotic action. It is particularly relevant in the study of mycobacterial infections, where it is used to understand the inhibitory effects on bacterial RNA polymerase. The compound is employed in laboratory experiments to assess its efficacy against various strains of mycobacteria, including those that are resistant to other antibiotics. Research involving rifabutin also focuses on its role in biofilm formation and its potential to disrupt these complex bacterial communities. Moreover, the study of rifabutin includes investigations into the molecular mechanisms underlying bacterial resistance to this compound, which can provide valuable insights for the development of new strategies to combat resistant bacterial populations.


Rifabutin (CAS 72559-06-9) References

  1. Rifabutin for treating pulmonary tuberculosis.  |  Davies, G., et al. 2007. Cochrane Database Syst Rev. 2007: CD005159. PMID: 17943842
  2. Review article: rifabutin in the treatment of refractory Helicobacter pylori infection.  |  Gisbert, JP. and Calvet, X. 2012. Aliment Pharmacol Ther. 35: 209-21. PMID: 22129228
  3. Rifabutin Is Inactivated by Mycobacterium abscessus Arr.  |  Schäfle, D., et al. 2021. Antimicrob Agents Chemother. 65: PMID: 33318008
  4. Rifabutin for infusion (BV100) for the treatment of severe carbapenem-resistant Acinetobacter baumannii infections.  |  Trebosc, V., et al. 2021. Drug Discov Today. 26: 2099-2104. PMID: 34242796
  5. A Case Series of Rifabutin Use in Staphylococcal Prosthetic Infections.  |  Monk, M., et al. 2022. Microbiol Spectr. 10: e0038422. PMID: 35543561
  6. Effect of Rifabutin in Dolutegravir Dosing: A Case Series.  |  Mendoza, MA., et al. 2022. J Int Assoc Provid AIDS Care. 21: 23259582221111077. PMID: 36026587
  7. Rifabutin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy.  |  Brogden, RN. and Fitton, A. 1994. Drugs. 47: 983-1009. PMID: 7521834
  8. Clinical pharmacokinetics of rifabutin.  |  Skinner, MH. and Blaschke, TF. 1995. Clin Pharmacokinet. 28: 115-25. PMID: 7736687
  9. Rifabutin: a review with emphasis on its role in the prevention of disseminated Mycobacterium avium complex infection.  |  Maddix, DS., et al. 1994. Ann Pharmacother. 28: 1250-4. PMID: 7849340
  10. Rifabutin-associated uveitis.  |  Tseng, AL. and Walmsley, SL. 1995. Ann Pharmacother. 29: 1149-55. PMID: 8573961
  11. Rifabutin prophylaxis for Mycobacterium avium complex infection in patients with AIDS.  |  Siegal, FP. 1996. Clin Infect Dis. 22 Suppl 1: S23-30; discussion S30-2. PMID: 8785252
  12. Antimicrobial activity of rifabutin.  |  Kunin, CM. 1996. Clin Infect Dis. 22 Suppl 1: S3-13; discussion S13-4. PMID: 8785253
  13. Rifabutin therapy for disseminated Mycobacterium avium complex infection.  |  Sullam, PM. 1996. Clin Infect Dis. 22 Suppl 1: S37-41; discussion S41-2. PMID: 8785255

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Rifabutin, 100 mg

sc-208307
100 mg
$204.00