RICK Antibody (25): sc-136059

RICK Antibody (25) is a mouse monoclonal IgG1 antibody that detects RICK in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). RICK Antibody (25) is available in a non-conjugated form, allowing for versatile experimental use. RICK (receptor-interacting protein kinase), also known as RIP2 or CARDIAK, plays a crucial role in the regulation of apoptosis and the activation of nuclear factor kappa B (NFkB), which are essential processes in cellular responses to stress and inflammation. RICK is primarily located in the cytoplasm, where RICK interacts with various signaling complexes, particularly those associated with tumor necrosis factor receptors (TNFR). This localization is vital as RICK effectively mediates the signaling pathways that lead to cell survival or death, depending on the context. RICK in these complexes facilitates the recruitment of other proteins, such as those in the TNFR-associated factor (TRAF) family, which are critical for the downstream signaling events that determine cellular outcomes. Understanding the function and localization of RICK is important for elucidating RICK′s role in diseases characterized by dysregulated apoptosis and inflammation, making anti-RICK antibody (25) a valuable tool for researchers studying these pathways.

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RICK Antibody (25) References:

1. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems.  |  Kobayashi, K., et al. 2002. Nature. 416: 194-9. PMID: 11894098
2. RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs.  |  Park, JH., et al. 2007. J Immunol. 178: 2380-6. PMID: 17277144
3. The NOD2-RICK complex signals from the plasma membrane.  |  Lécine, P., et al. 2007. J Biol Chem. 282: 15197-207. PMID: 17355968
4. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.  |  He, S., et al. 2009. Cell. 137: 1100-11. PMID: 19524512
5. Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease.  |  Majdi, A., et al. 2020. J Hepatol. 72: 627-635. PMID: 31760070
6. Receptor-interacting Protein Kinase 2 Is an Immunotherapy Target in Pancreatic Cancer.  |  Sang, W., et al. 2024. Cancer Discov. 14: 326-347. PMID: 37824278
7. Apoptosis mediated by the TNF-related cytokine and receptor families.  |  Ware, CF., et al. 1996. J Cell Biochem. 60: 47-55. PMID: 8825415
8. Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B.  |  Marsters, SA., et al. 1996. Curr Biol. 6: 1669-76. PMID: 8994832
9. TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival.  |  Lee, SY., et al. 1997. Immunity. 7: 703-13. PMID: 9390693
10. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.  |  Inohara, N., et al. 1998. J Biol Chem. 273: 12296-300. PMID: 9575181
11. RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.  |  McCarthy, JV., et al. 1998. J Biol Chem. 273: 16968-75. PMID: 9642260
12. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.  |  Thome, M., et al. 1998. Curr Biol. 8: 885-8. PMID: 9705938

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RICK Antibody (25) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-RICK Antibody (25) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RICK Antibody (25) Specifications

Alternate Product Name: RIPK2

Product Clone Name: 25

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 333-532

Epitope Target: RICK

Epitope Species: human

Product Reactivity/Detection: RICK

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for RICK Antibody (25): N/A

The preferred RICK antibody is RICK Antibody (A-10): sc-166765.