Reveromycin C (CAS 144860-69-5)

Reveromycin C, recorded under the CAS number 144860-69-5, is a bioactive compound that belongs to the reveromycin group, extracted from the Streptomyces species. This molecule features a distinct structural framework that includes a spiroacetal ring, a characteristic shared among reveromycins, which is crucial for its biological activities. The primary mechanism through which Reveromycin C exerts its action is by inhibiting isoleucyl-tRNA synthetase, an enzyme pivotal in the protein synthesis process. This inhibition specifically disrupts the incorporation of the amino acid isoleucine into proteins, thereby hindering the overall process of protein synthesis. This targeted action makes Reveromycin C a valuable tool in biochemical research, particularly in studies focused on understanding the regulation of protein synthesis and its impact on cellular functions. In scientific studies, Reveromycin C has been utilized to explore the dynamics of cellular metabolism and growth under conditions where protein synthesis is compromised. It aids in elucidating the cellular responses to protein synthesis inhibition, including mechanisms of cell cycle control and apoptosis. Such research provides deeper insights into the cellular and molecular pathways that control growth and survival, offering a broader understanding of how cells adapt to metabolic and synthetic challenges.