Molecular structure of Repaglinide Acyl-β-D-glucuronide, CAS Number: 1309112-13-7
Repaglinide Acyl-β-D-glucuronide (CAS 1309112-13-7)
Alternate Names:
1-[2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoate] β-D-Glucopyranuronic Acid
CAS Number:
1309112-13-7
Molecular Weight:
628.71
Molecular Formula:
C33H44N2O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Repaglinide Acyl-β-D-glucuronide is a metabolite of repaglinide. This metabolite is formed through the process of glucuronidation, where a glucuronic acid molecule is attached to the parent compound. This conjugation reaction is catalyzed by UDP-glucuronosyltransferase enzymes in the liver.
Repaglinide Acyl-β-D-glucuronide (CAS 1309112-13-7) References
- Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model. | Ménochet, K., et al. 2012. J Pharmacol Exp Ther. 341: 2-15. PMID: 22190645
- The pharmacokinetics and hepatic disposition of repaglinide in pigs: mechanistic modeling of metabolism and transport. | Sjögren, E., et al. 2012. Mol Pharm. 9: 823-41. PMID: 22352317
- A comprehensive assessment of repaglinide metabolic pathways: impact of choice of in vitro system and relative enzyme contribution to in vitro clearance. | Säll, C., et al. 2012. Drug Metab Dispos. 40: 1279-89. PMID: 22451699
- Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes. | Ménochet, K., et al. 2012. Drug Metab Dispos. 40: 1744-56. PMID: 22665271
- Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations. | Cantrill, C. and Houston, JB. 2017. J Pharm Sci. 106: 2815-2825. PMID: 28478131
- Hepatic Organic Anion Transporting Polypeptide-Mediated Clearance in the Beagle Dog: Assessing In Vitro-In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance. | Matsunaga, N., et al. 2019. Drug Metab Dispos. 47: 215-226. PMID: 30593544
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Repaglinide Acyl-β-D-glucuronide, 1 mg | sc-219960 | 1 mg | $360.00 | |||
Repaglinide Acyl-β-D-glucuronide, 10 mg | sc-219960A | 10 mg | $2290.00 |