RAW 264.7 Whole Cell Lysate: sc-2211

RAW 264.7 is a cell line that is derived from a murine Abelson leukemia virus-induced tumor extensively used to investigate immune responses and macrophage function. This lysate offers a vital resource for studying macrophage activation and the cellular mechanisms underlying their role in innate immunity. Researchers utilize RAW 264.7 lysate to examine the pathways triggered by various immunostimulants, including bacterial components like lipopolysaccharide (LPS) and cytokines, which induce macrophage activation via toll-like receptors (TLRs). This activation leads to signaling through the NF-κB and MAPK pathways, critical for the production of inflammatory cytokines and the orchestration of immune responses. The lysate is also used to study the macrophage's role in phagocytosis, antigen presentation, and the generation of reactive oxygen species (ROS). Additionally, it allows for exploration of the interactions between macrophages and other cell types within the immune system. By using RAW 264.7 cell lysate, scientists gain insights into the complex regulatory mechanisms that govern macrophage behavior in health and disease, thereby enriching our understanding of immunological processes.

RAW 264.7 Whole Cell Lysate References:

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