Rae-1δ Antibody (RD-41): sc-53602

Rae-1δ Antibody (RD-41) is a hamster monoclonal IgG1 antibody that detects Rae-1δ in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. Rae-1δ is a crucial ligand for the NKG2D receptor, which plays a significant role in the immune response, particularly in the activation of natural killer (NK) cells against tumor and infected cells. The expression of Rae-1δ is typically low in normal adult tissues but is significantly upregulated in various tumors, making Rae-1δ an important marker for tumor immunity. This upregulation allows NK cells to recognize and attack cancerous cells more effectively, highlighting Rae-1δ′s importance in immune surveillance and potential cancer therapies. The interaction between Rae-1δ and NKG2D is characterized by a high affinity, which enhances the immune response against malignancies. Furthermore, Rae-1δ competes with other ligands for binding to NKG2D, ensuring that the immune system can effectively target cells expressing these ligands. Using anti-Rae-1δ antibody (RD-41) in research can provide valuable insights into the mechanisms of immune activation and the role of NKG2D ligands in tumor biology.