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rac Cycloserine (CAS 68-39-3)

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Alternate Names:
4-Amino-3-isoxazolidinone; (±)-3-Oxoisooxazolidin-4-amine; DL-Cycloserine
Application:
rac Cycloserine is an GPT(alanine aminotransferase) and ketosphinganine synthetase inhibitor
CAS Number:
68-39-3
Molecular Weight:
102.09
Molecular Formula:
C3H6N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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rac Cycloserine is a compound that is of interest in stereochemistry and enzymology research. As a racemic mixture, it contains both the D and L enantiomers of cycloserine, which allows researchers to study the effects of chirality on biological systems. It is frequently used to investigate the mechanisms of action of enzymes that are stereoselective, as well as to explore the enantioselective processes within microbial metabolism. In the study of amino acid analogs, rac Cycloserine serves as a structural analog to investigate the function and structure of proteins, especially those involved in the synthesis of bacterial cell walls. Additionally, the compound is used in research exploring the biosynthesis and inhibition of amino acids. Understanding the role of rac Cycloserine in these systems provides valuable insights into fundamental biochemical processes and the design of enzyme inhibitors.


rac Cycloserine (CAS 68-39-3) References

  1. Inhibition of translation and cell growth by minigene expression.  |  Tenson, T., et al. 1999. J Bacteriol. 181: 1617-22. PMID: 10049395
  2. Beta-cyanoalanine synthase: purification and characterization.  |  Akopyan, TN., et al. 1975. Proc Natl Acad Sci U S A. 72: 1617-21. PMID: 1055433
  3. Mechanism of synergy between epigallocatechin gallate and beta-lactams against methicillin-resistant Staphylococcus aureus.  |  Zhao, WH., et al. 2001. Antimicrob Agents Chemother. 45: 1737-42. PMID: 11353619
  4. Differences in 2-oxoglutarate dehydrogenase regulation in liver and kidney.  |  Smith, BC., et al. 1992. Biochem J. 284 (Pt 3): 819-26. PMID: 1352447
  5. Formation of DL-cycloserine from the methyl ester of dl-aminoxyalanine.  |  CONCILIO, C., et al. 1958. Arch Int Pharmacodyn Ther. 117: 321-7. PMID: 13606942
  6. [Comparative study of functional and morphological changes under the action of dl-cycloserine on the central nervous system].  |  RAZUMOVA, IL. 1963. Zh Vyssh Nerv Deiat Im I P Pavlova. 13: 352-60. PMID: 13973367
  7. Inhibition of glutamic-pyruvic transaminase by DL-cycloserine and other compounds.  |  VYSHEPAN, ED., et al. 1961. Biull Eksp Biol Med. 52: 819-22. PMID: 14040130
  8. Purification and Characterization of Cystathionine (beta)-Lyase from Lactococcus lactis subsp. cremoris B78 and Its Possible Role in Flavor Development in Cheese.  |  Alting, AC., et al. 1995. Appl Environ Microbiol. 61: 4037-42. PMID: 16535166
  9. Purification and Characterization of Cystathionine (gamma)-Lyase from Lactococcus lactis subsp. cremoris SK11: Possible Role in Flavor Compound Formation during Cheese Maturation.  |  Bruinenberg, PG., et al. 1997. Appl Environ Microbiol. 63: 561-6. PMID: 16535512
  10. Antibacterial and antifungal activities of new acylated derivatives of epigallocatechin gallate.  |  Matsumoto, Y., et al. 2012. Front Microbiol. 3: 53. PMID: 22355295
  11. Functional role of glucose metabolism, osmotic stress, and sodium-glucose cotransporter isoform-mediated transport on Na+/H+ exchanger isoform 3 activity in the renal proximal tubule.  |  Pessoa, TD., et al. 2014. J Am Soc Nephrol. 25: 2028-39. PMID: 24652792
  12. [Chemical and microbiological determination of the liberation of antitubercular agents from emulsion and suspension systems. 1. Streptomycin sulfate, rifamycin SV sodium, DL-cycloserine].  |  Maa Bared, AG., et al. 1970. Pharmazie. 25: 161-8. PMID: 5453802
  13. Inhibition of urea-cycle activity by high concentrations of alanine.  |  Hensgens, HE. and Meijer, AJ. 1980. Biochem J. 186: 1-4. PMID: 7370000
  14. The Saccharomyces cerevisiae YCC5 (YCL025c) gene encodes an amino acid permease, Agp1, which transports asparagine and glutamine.  |  Schreve, JL., et al. 1998. J Bacteriol. 180: 2556-9. PMID: 9573211
  15. The glutathione dependence of inorganic sulfate formation from L- or D-cysteine in isolated rat hepatocytes.  |  Huang, J., et al. 1998. Chem Biol Interact. 110: 189-202. PMID: 9609386

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

rac Cycloserine, 100 mg

sc-212728
100 mg
$262.00