Rac-Cotinine-d3 N-β-D-Glucuronide
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Rac-Cotinine-d3 N-β-D-Glucuronide is a chemically labeled derivative of cotinine N-β-D-glucuronide, which is a metabolite of nicotine. In analytical chemistry, Rac-Cotinine-d3 N-β-D-Glucuronide is used as an internal standard for the quantification of cotinine glucuronide in biological samples via methods such as liquid chromatography-mass spectrometry (LC-MS). The incorporation of deuterium atoms enhances the accuracy and precision of these measurements by providing distinct mass spectral properties that help differentiate the labeled standard from the occurring metabolites. Rac-Cotinine-D3 N-Β-D-Glucuronide is particularly in kinetic studies where understanding the metabolism and excretion of nicotine. It could used to map out how nicotine and its metabolites are processed in biological samples, including their conjugation reactions like glucuronidation. Cotinine-d3 N-beta-D-Glucuronide is a major Nicotine metabolite in carcinogen.
Rac-Cotinine-d3 N-β-D-Glucuronide References
- A novel validated procedure for the determination of nicotine, eight nicotine metabolites and two minor tobacco alkaloids in human plasma or urine by solid-phase extraction coupled with liquid chromatography-electrospray ionization-tandem mass spectrometry. | Miller, EI., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 725-37. PMID: 20097626
- Validation of a liquid chromatography-tandem mass spectrometry method for the detection of nicotine biomarkers in hair and an evaluation of wash procedures for removal of environmental nicotine. | Miller, EI., et al. 2011. J Anal Toxicol. 35: 321-32. PMID: 21740688
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rac-Cotinine-d3 N-β-D-Glucuronide, 1 mg | sc-217952 | 1 mg | $316.00 |