Molecular structure of (R)-CPP, CAS Number: 126453-07-4
(R)-CPP (CAS 126453-07-4)
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Alternate Names:
3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Application:
(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism
CAS Number:
126453-07-4
Molecular Weight:
252.2
Molecular Formula:
C8H17N2O5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(R)-CPP is a highly potent piperazine-based NMDA receptor antagonist. (R)-CPP is the more active isomer of racemic CPP preparations. (R)-CPP demonstrates selectivity for NMDAε1 receptors with an IC50 value of 41 nM. (R)-CPP is an inhibitor of NMDA ε 1, NMDA ε 2 and NMDA ε 3.
(R)-CPP (CAS 126453-07-4) References
- Convulsant actions of the neurosteroid pregnenolone sulfate in mice. | Kokate, TG., et al. 1999. Brain Res. 831: 119-24. PMID: 10411990
- Functional characterization of N-methyl-D-aspartic acid-gated channels in bone cells. | Laketić-Ljubojević, I., et al. 1999. Bone. 25: 631-7. PMID: 10593407
- Local glutamate receptor antagonism in the rat prefrontal cortex disrupts response inhibition in a visuospatial attentional task. | Murphy, ER., et al. 2005. Psychopharmacology (Berl). 179: 99-107. PMID: 15678364
- The effect of competitive antagonist chain length on NMDA receptor subunit selectivity. | Feng, B., et al. 2005. Neuropharmacology. 48: 354-9. PMID: 15721167
- Attention deficit induced by blockade of N-methyl D-aspartate receptors in the prefrontal cortex is associated with enhanced glutamate release and cAMP response element binding protein phosphorylation: role of metabotropic glutamate receptors 2/3. | Pozzi, L., et al. 2011. Neuroscience. 176: 336-48. PMID: 21193020
- Impulsive behaviour induced by both NMDA receptor antagonism and GABAA receptor activation in rat ventromedial prefrontal cortex. | Murphy, ER., et al. 2012. Psychopharmacology (Berl). 219: 401-10. PMID: 22101355
- An intra-cerebral drug delivery system for freely moving animals. | Spieth, S., et al. 2012. Biomed Microdevices. 14: 799-809. PMID: 22622711
- Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases. | Weilinger, NL., et al. 2012. J Neurosci. 32: 12579-88. PMID: 22956847
- Blockade of ventral midbrain NMDA receptors enhances brain stimulation reward: a preferential role for GluN2A subunits. | Bergeron, S. and Rompré, PP. 2013. Eur Neuropsychopharmacol. 23: 1623-35. PMID: 23352316
- Synaptic GluN2A and GluN2B containing NMDA receptors within the superficial dorsal horn activated following primary afferent stimulation. | Tong, CK. and MacDermott, AB. 2014. J Neurosci. 34: 10808-20. PMID: 25122884
- CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity. | Davies, J., et al. 1986. Brain Res. 382: 169-73. PMID: 2876749
- NR2A-NMDA Receptor Blockade Reverses the Lack of Morphine Analgesia Without Affecting Chronic Pain Status in a Fibromyalgia-Like Mouse Model. | Neyama, H., et al. 2020. J Pharmacol Exp Ther. 373: 103-112. PMID: 31941720
- Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP. | Zhu, M., et al. 2022. Neuropharmacology. 218: 109215. PMID: 35977628
Inhibitor of:
NMDA epsilon 2, and NMDA epsilon 3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-CPP, 1 mg | sc-202308 | 1 mg | $50.00 | |||
(R)-CPP, 10 mg | sc-202308A | 10 mg | $325.00 |