Molecular structure of (R)-(+)-Acenocoumarol, CAS Number: 66556-77-2
(R)-(+)-Acenocoumarol (CAS 66556-77-2)
Alternate Names:
(R)-Acenocoumarin; (R)-Nicoumalone
Application:
(R)-(+)-Acenocoumarol is an inhibitor of vitamin K epoxide reductase
CAS Number:
66556-77-2
Molecular Weight:
353.3
Molecular Formula:
C19H15NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. It has higher intrinsic anticoagulant potency than warfarin and phenprocoumon, when evaluated in vitro. Acenocoumarol has a single chiral center that gives rise to two different enantiomeric forms. (R)-(+)-Acenocoumarol has a longer plasma elimination half-life (6.6 hours) and slower plasma clearance (1.9 L/h), compared to the (S)-(−)-enantiomer (1.8 hours, 28.5 L/h). The R-enantiomer is rapidly absorbed from the gastrointestinal tract with essentially complete oral bioavailability, whereas (S)-(−)-acenocoumarol undergoes extensive first-pass metabolism.
(R)-(+)-Acenocoumarol (CAS 66556-77-2) References
- Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol. | Ufer, M. 2005. Clin Pharmacokinet. 44: 1227-46. PMID: 16372822
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(R)-(+)-Acenocoumarol, 1 mg | sc-205484 | 1 mg | $220.00 | |||
(R)-(+)-Acenocoumarol, 5 mg | sc-205484A | 5 mg | $992.00 |